| Gene Symbol | AKR1D1 |
|---|---|
| Entrez Gene | 6718 |
| Alt Symbol | 3o5bred, CBAS2, SRD5B1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | aldo-keto reductase family 1, member D1 |
| Other Description | 3-oxo-5-beta-steroid 4-dehydrogenase|delta 4-3-ketosteroid-5-beta-reductase|delta(4)-3-ketosteroid 5-beta-reductase|delta(4)-3-oxosteroid 5-beta-reductase|steroid-5-beta-reductase, beta polypeptide 1 (3-oxo-5 beta-steroid delta 4-dehydrogenase beta 1) |
| Swissprots | P51857 A1L4P6 B4DPN8 B4DPN3 A8K060 |
| Accessions | AAG39381 EAL24049 EAW83881 EAW83882 P51857 AK058142 BAB71682 AK289425 BAF82114 AK298421 BAG60645 AK298428 BAG60650 BC130625 AAI30626 BC130627 AAI30628 BG210362 CB111926 FM160741 CAQ55951 FM160742 CAQ55952 FM160743 CAQ55953 HQ258384 ADR83138 Z28339 CAA82193 NM_001190906 NP_001177835 NM_001190907 NP_001177836 NM_005989 NP_005980 |
| Function | Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates. {ECO:0000269|PubMed:11342103}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Highly expressed in liver. Expressed in testis and weakly in colon. {ECO:0000269|PubMed:11342103}. |
| Top Pathways | Primary bile acid biosynthesis, Steroid hormone biosynthesis |