| Gene Symbol |
UPF1
|
| Entrez Gene |
5976
|
| Alt Symbol |
HUPF1, NORF1, RENT1, pNORF1, smg-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UPF1 regulator of nonsense transcripts homolog (yeast)
|
| Other Description |
ATP-dependent helicase RENT1|delta helicase|nonsense mRNA reducing factor 1|regulator of nonsense transcripts 1|smg-2 homolog, nonsense mediated mRNA decay factor|up-frameshift mutation 1 homolog|up-frameshift suppressor 1 homolog|yeast Upf1p homolog
|
| Swissprots |
Q86Z25 Q92900 O00239 Q92842 O43343
|
| Accessions |
AAB94785 AAC09016 AIA19311 AIA19312 AIA19313 AIA19314 AIA19315 AIA19316 AIA19317 AIA19318 AIA19319 AIA19320 AIA19321 AIA19322 AIA19323 AIA19324 AIA19325 AIA19326 AIA19327 AIA19328 EAW84738 EAW84739 EAW84740 EAW84741 EAW84742 Q92900 AF074016 AAC26788 AK125797 BAC86297 AK128727 BAG54717 BC034291 BC039817 AAH39817 BE243084 BM969672 BQ950083 BX331580 BX364728 CB960545 D86988 BAA19664 U59323 AAC51140 U65533 AAC50771 NM_001297549 NP_001284478 NM_002911 NP_002902
|
| Function |
RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1- eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosph
|
| Subcellular Location |
Cytoplasm. Cytoplasm, P-body. Nucleus. Note=Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
RNA transport, mRNA surveillance pathway
|