UPF1

Gene Symbol	UPF1
Entrez Gene	5976
Alt Symbol	HUPF1, NORF1, RENT1, pNORF1, smg-2
Species	Human
Gene Type	protein-coding
Description	UPF1 regulator of nonsense transcripts homolog (yeast)
Other Description	ATP-dependent helicase RENT1|delta helicase|nonsense mRNA reducing factor 1|regulator of nonsense transcripts 1|smg-2 homolog, nonsense mediated mRNA decay factor|up-frameshift mutation 1 homolog|up-frameshift suppressor 1 homolog|yeast Upf1p homolog
Swissprots	Q86Z25 Q92900 O00239 Q92842 O43343
Accessions	AAB94785 AAC09016 AIA19311 AIA19312 AIA19313 AIA19314 AIA19315 AIA19316 AIA19317 AIA19318 AIA19319 AIA19320 AIA19321 AIA19322 AIA19323 AIA19324 AIA19325 AIA19326 AIA19327 AIA19328 EAW84738 EAW84739 EAW84740 EAW84741 EAW84742 Q92900 AF074016 AAC26788 AK125797 BAC86297 AK128727 BAG54717 BC034291 BC039817 AAH39817 BE243084 BM969672 BQ950083 BX331580 BX364728 CB960545 D86988 BAA19664 U59323 AAC51140 U65533 AAC50771 NM_001297549 NP_001284478 NM_002911 NP_002902
Function	RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1- eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosph
Subcellular Location	Cytoplasm. Cytoplasm, P-body. Nucleus. Note=Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm.
Tissue Specificity	Ubiquitous.
Top Pathways	RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RENT1 / UPF1 Antibody Blocking Peptide - LS-E6354 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RENT1 / UPF1 Antibody Blocking Peptide - LS-E13012 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RENT1/UPF1/hUPF1 Protein - H00005976-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RENT1/UPF1/hUPF1 Peptide - P0648 from Novus Biologicals Category Peptide Species Human

RENT1-Antibody-N-term-Blocking-Peptide - BP1905b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UPF1 Protein Lysate (APL10353) - APL10353 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

UPF1 Blocking Peptide - 33R-7945 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UPF1 / RENT1 - H00005976-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

UPF1 / RENT1 - H00005976-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

UPF1 fusion protein - ag16195 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human UPF1, His-tagged - UPF1-30951TH from Creative Biomart Category Protein Source E. coli

Recombinant Human UPF1, GST-tagged - UPF1-3603H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human UPF1 - UPF1-534H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Regulator of nonsense transcripts 1(UPF1) ,partial - CSB-YP838819HU CSB-EP838819HU CSB-BP838819HU CSB-MP838819HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

UPF1 / RENT1 - TP308018 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RENT1/UPF1/hUPF1 Recombinant Protein Antigen - NBP1-89642PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RENT1/UPF1/hUPF1 Recombinant Protein Antigen - NBP1-89641PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RENT1 Blocking Peptide (OESA09477) - OESA09477 from Aviva Systems Biology Category Peptide Prices $200.00 Sizes 50 µg

RENT1 Blocking Peptide (OESA09478) - OESA09478 from Aviva Systems Biology Category Peptide Prices $200.00 Sizes 50 µg

RENT1 Blocking Peptide (OESA09479) - OESA09479 from Aviva Systems Biology Category Peptide Prices $200.00 Sizes 50 µg

UPF1 Protein Lysate - orb333287 from Biorbyt Category Protein Prices $400.00 Sizes 200 μg Species Human

RENT1-Antibody-Center-Blocking-Peptide - BP1905c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RENT1-Antibody-N-term-E22-Blocking-Peptide - BP1905a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UPF1 Peptide, Human - M34GP17105H from Creative Peptides Category Peptide Source Synthetic. Species Human

Regulator of nonsense transcripts 1 (UPF1), partial, Recombinant Protein - MBS1481478 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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