| Gene Symbol |
Mef2b
|
| Entrez Gene |
17259
|
| Alt Symbol |
AI451606
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
myocyte enhancer factor 2B
|
| Other Description |
myocyte-specific enhancer factor 2B
|
| Swissprots |
O55087 O55088 O55089 O55090 O55231 Q61843
|
| Accessions |
BAA24539 EDL28788 EDL28789 O55087 BB867153 BC045147 AAH45147 CO811773 D87833 BAA24542 D87834 BAA24543 D87835 BAA24544 D87836 BAA24545 NM_001045484 NP_001038949 NM_008578 NP_032604
|
| Function |
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription. {ECO:0000269|PubMed:8668199, ECO:0000269|PubMed:9443808}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00251}.
|
| Tissue Specificity |
Highest expression found in embryonic heart and skeletal muscle. Low levels found in adult spleen, lung and testis while no expression is found in adult heart, brain or skeletal muscle. {ECO:0000269|PubMed:7646512, ECO:0000269|PubMed:8668199, ECO:0000269|PubMed:9443808}.
|
| Top Pathways |
cGMP-PKG signaling pathway
|