Gene Symbol | Mef2b |
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Entrez Gene | 17259 |
Alt Symbol | AI451606 |
Species | Mouse |
Gene Type | protein-coding |
Description | myocyte enhancer factor 2B |
Other Description | myocyte-specific enhancer factor 2B |
Swissprots | O55087 O55088 O55089 O55090 O55231 Q61843 |
Accessions | BAA24539 EDL28788 EDL28789 O55087 BB867153 BC045147 AAH45147 CO811773 D87833 BAA24542 D87834 BAA24543 D87835 BAA24544 D87836 BAA24545 NM_001045484 NP_001038949 NM_008578 NP_032604 |
Function | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription. {ECO:0000269|PubMed:8668199, ECO:0000269|PubMed:9443808}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00251}. |
Tissue Specificity | Highest expression found in embryonic heart and skeletal muscle. Low levels found in adult spleen, lung and testis while no expression is found in adult heart, brain or skeletal muscle. {ECO:0000269|PubMed:7646512, ECO:0000269|PubMed:8668199, ECO:0000269|PubMed:9443808}. |
Top Pathways | cGMP-PKG signaling pathway |
MEF-2B CRISPR/Cas9 KO Plasmid (m) - sc-421619 from Santa Cruz Biotechnology
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MEF-2B HDR Plasmid (m) - sc-421619-HDR from Santa Cruz Biotechnology
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MEF-2B Double Nickase Plasmid (m) - sc-421619-NIC from Santa Cruz Biotechnology
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MEF-2B Double Nickase Plasmid (m2) - sc-421619-NIC-2 from Santa Cruz Biotechnology
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MEF-2B CRISPR Activation Plasmid (m) - sc-421619-ACT from Santa Cruz Biotechnology
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MEF-2B CRISPR Activation Plasmid (m2) - sc-421619-ACT-2 from Santa Cruz Biotechnology
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MEF-2B Lentiviral Activation Particles (m) - sc-421619-LAC from Santa Cruz Biotechnology
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MEF-2B Lentiviral Activation Particles (m2) - sc-421619-LAC-2 from Santa Cruz Biotechnology
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MEF-2B siRNA (m) - sc-38061 from Santa Cruz Biotechnology
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MEF-2B shRNA Plasmid (m) - sc-38061-SH from Santa Cruz Biotechnology
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MEF-2B shRNA (m) Lentiviral Particles - sc-38061-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU163391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN35444 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35444 from Sigma-Aldrich
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shRNA set against Mouse MEF2B (NM_008578.2) - SHH340187 from Creative biogene
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shRNA set against Mouse Mef2b(NM_008578.2) - SHH183863 from Creative biogene
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shRNA set against Mouse Mef2b(NM_001045484.1) - SHH183899 from Creative biogene
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MEF2B miRNA 3'UTR clone - MiUTR1M-07043 from Creative biogene
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MEF2B miRNA 3'UTR clone - MiUTR1M-07044 from Creative biogene
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