| Gene Symbol | SFTPD |
|---|---|
| Entrez Gene | 6441 |
| Alt Symbol | COLEC7, PSP-D, SFTP4, SP-D |
| Species | Human |
| Gene Type | protein-coding |
| Description | surfactant protein D |
| Other Description | collectin 7|collectin-7|lung surfactant protein D|pulmonary surfactant apoprotein|pulmonary surfactant-associated protein D|surfactant, pulmonary-associated protein D|surfactant-associated protein, pulmonary 4 |
| Swissprots | Q5T0M3 P35247 Q9UCJ3 Q9UCJ2 Q6FH08 Q8TCD8 Q86YK9 |
| Accessions | AAB59450 AAO22991 AEQ16458 EAW80419 EAW80420 EAW80421 P35247 BC022318 AAH22318 BI820265 BM985387 CR541948 CAG46746 X65018 CAA46152 XM_011540087 XP_011538389 XM_011540088 XP_011538390 NM_003019 NP_003010 |
| Function | Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. {ECO:0000269|PubMed:23478426}. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. |
| Tissue Specificity | Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes). {ECO:0000269|PubMed:23478426}. |
| Top Pathways | Phagosome |