Gene Symbol | SFTPD |
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Entrez Gene | 6441 |
Alt Symbol | COLEC7, PSP-D, SFTP4, SP-D |
Species | Human |
Gene Type | protein-coding |
Description | surfactant protein D |
Other Description | collectin 7|collectin-7|lung surfactant protein D|pulmonary surfactant apoprotein|pulmonary surfactant-associated protein D|surfactant, pulmonary-associated protein D|surfactant-associated protein, pulmonary 4 |
Swissprots | Q5T0M3 P35247 Q9UCJ3 Q9UCJ2 Q6FH08 Q8TCD8 Q86YK9 |
Accessions | AAB59450 AAO22991 AEQ16458 EAW80419 EAW80420 EAW80421 P35247 BC022318 AAH22318 BI820265 BM985387 CR541948 CAG46746 X65018 CAA46152 XM_011540087 XP_011538389 XM_011540088 XP_011538390 NM_003019 NP_003010 |
Function | Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. {ECO:0000269|PubMed:23478426}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. |
Tissue Specificity | Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes). {ECO:0000269|PubMed:23478426}. |
Top Pathways | Phagosome |
SP-D CRISPR/Cas9 KO Plasmid (h) - sc-401572 from Santa Cruz Biotechnology
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SP-D HDR Plasmid (h) - sc-401572-HDR from Santa Cruz Biotechnology
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SP-D Double Nickase Plasmid (h) - sc-401572-NIC from Santa Cruz Biotechnology
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SP-D Double Nickase Plasmid (h2) - sc-401572-NIC-2 from Santa Cruz Biotechnology
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SP-D CRISPR Activation Plasmid (h) - sc-401572-ACT from Santa Cruz Biotechnology
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SP-D CRISPR Activation Plasmid (h2) - sc-401572-ACT-2 from Santa Cruz Biotechnology
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SP-D Lentiviral Activation Particles (h) - sc-401572-LAC from Santa Cruz Biotechnology
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SP-D Lentiviral Activation Particles (h2) - sc-401572-LAC-2 from Santa Cruz Biotechnology
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SP-D siRNA (h) - sc-36541 from Santa Cruz Biotechnology
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SP-D shRNA Plasmid (h) - sc-36541-SH from Santa Cruz Biotechnology
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SP-D shRNA (h) Lentiviral Particles - sc-36541-V from Santa Cruz Biotechnology
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SP-D RNAi - H00006441-R01 from Novus Biologicals
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MISSION® esiRNA - EHU011071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19212 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19212 from Sigma-Aldrich
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SFTPD siRNA (Human) - CRH4352 from Cohesion Biosciences
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SFTPD - MBS829513 from MyBioSource
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shRNA set against Human SFTPD (NM_003019.4) - SHH406088 from Creative biogene
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Human SFTPD siRNA - orb264854 from Biorbyt
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SFTPD shRNA Plasmid (Human) - CHH4352 from Cohesion Biosciences
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SFTPD miRNA 3'UTR clone - MiUTR1H-09341 from Creative biogene
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