| Gene Symbol |
PRMT8
|
| Entrez Gene |
56341
|
| Alt Symbol |
HRMT1L3, HRMT1L4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein arginine methyltransferase 8
|
| Other Description |
HMT1 hnRNP methyltransferase-like 3|heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4|protein arginine N-methyltransferase 4|protein arginine N-methyltransferase 8
|
| Swissprots |
Q8TBJ8 Q9NR22 B2RDP0
|
| Accessions |
EAW88861 EAW88862 Q9NR22 AB209027 BAD92264 AF263539 AAF91390 AK026786 BAB15553 AK093651 AK315619 BAG37987 BC022458 AAH22458 DA200375 DQ892381 ABM83307 DQ895593 ABM86519 XM_011520968 XP_011519270 XM_011520969 XP_011519271 NM_001256537 NR_046301 NM_001256536 NP_001243465 NM_019854 NP_062828
|
| Function |
Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS. {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:17925405, ECO:0000269|PubMed:18320585}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:18320585}; Lipid-anchor {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:18320585}; Cytoplasmic side {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:18320585}.
|
| Tissue Specificity |
Brain-specific. {ECO:0000269|PubMed:16051612}.
|
![Western Blot: PRMT8 Overexpression Lysate (Adult Normal) [NBL1-14798] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PRMT8.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6444_PRMT8%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14798-img0002.jpg)