Gene Symbol | PRMT8 |
---|---|
Entrez Gene | 56341 |
Alt Symbol | HRMT1L3, HRMT1L4 |
Species | Human |
Gene Type | protein-coding |
Description | protein arginine methyltransferase 8 |
Other Description | HMT1 hnRNP methyltransferase-like 3|heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4|protein arginine N-methyltransferase 4|protein arginine N-methyltransferase 8 |
Swissprots | Q8TBJ8 Q9NR22 B2RDP0 |
Accessions | EAW88861 EAW88862 Q9NR22 AB209027 BAD92264 AF263539 AAF91390 AK026786 BAB15553 AK093651 AK315619 BAG37987 BC022458 AAH22458 DA200375 DQ892381 ABM83307 DQ895593 ABM86519 XM_011520968 XP_011519270 XM_011520969 XP_011519271 NM_001256537 NR_046301 NM_001256536 NP_001243465 NM_019854 NP_062828 |
Function | Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS. {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:17925405, ECO:0000269|PubMed:18320585}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:18320585}; Lipid-anchor {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:18320585}; Cytoplasmic side {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:18320585}. |
Tissue Specificity | Brain-specific. {ECO:0000269|PubMed:16051612}. |