Gene Symbol | PRMT8 |
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Entrez Gene | 56341 |
Alt Symbol | HRMT1L3, HRMT1L4 |
Species | Human |
Gene Type | protein-coding |
Description | protein arginine methyltransferase 8 |
Other Description | HMT1 hnRNP methyltransferase-like 3|heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4|protein arginine N-methyltransferase 4|protein arginine N-methyltransferase 8 |
Swissprots | Q8TBJ8 Q9NR22 B2RDP0 |
Accessions | EAW88861 EAW88862 Q9NR22 AB209027 BAD92264 AF263539 AAF91390 AK026786 BAB15553 AK093651 AK315619 BAG37987 BC022458 AAH22458 DA200375 DQ892381 ABM83307 DQ895593 ABM86519 XM_011520968 XP_011519270 XM_011520969 XP_011519271 NM_001256537 NR_046301 NM_001256536 NP_001243465 NM_019854 NP_062828 |
Function | Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS. {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:17925405, ECO:0000269|PubMed:18320585}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:18320585}; Lipid-anchor {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:18320585}; Cytoplasmic side {ECO:0000269|PubMed:16051612, ECO:0000269|PubMed:18320585}. |
Tissue Specificity | Brain-specific. {ECO:0000269|PubMed:16051612}. |
PRMT8 CRISPR/Cas9 KO Plasmid (h) - sc-404371 from Santa Cruz Biotechnology
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PRMT8 HDR Plasmid (h) - sc-404371-HDR from Santa Cruz Biotechnology
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PRMT8 Double Nickase Plasmid (h) - sc-404371-NIC from Santa Cruz Biotechnology
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PRMT8 Double Nickase Plasmid (h2) - sc-404371-NIC-2 from Santa Cruz Biotechnology
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PRMT8 CRISPR Activation Plasmid (h) - sc-404371-ACT from Santa Cruz Biotechnology
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PRMT8 CRISPR Activation Plasmid (h2) - sc-404371-ACT-2 from Santa Cruz Biotechnology
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PRMT8 Lentiviral Activation Particles (h) - sc-404371-LAC from Santa Cruz Biotechnology
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PRMT8 Lentiviral Activation Particles (h2) - sc-404371-LAC-2 from Santa Cruz Biotechnology
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PRMT8 siRNA (h) - sc-95787 from Santa Cruz Biotechnology
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PRMT8 shRNA Plasmid (h) - sc-95787-SH from Santa Cruz Biotechnology
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PRMT8 shRNA (h) Lentiviral Particles - sc-95787-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU133921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17447 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17447 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07318 from Sigma-Aldrich
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PRMT8 siRNA (Human) - CRJ1137 from Cohesion Biosciences
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PRMT8 RNAi - H00056341-R01 from Novus Biologicals
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shRNA set against Human PRMT8 (NM_019854.4) - SHH383392 from Creative biogene
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Human PRMT8 siRNA - orb271638 from Biorbyt
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PRMT8 shRNA Plasmid (Human) - CHJ1137 from Cohesion Biosciences
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PRMT8 miRNA 3'UTR clone - MiUTR3H-11022 from Creative biogene
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