| Gene Symbol |
Galnt1
|
| Entrez Gene |
14423
|
| Alt Symbol |
-
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1
|
| Other Description |
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1|galNAc-T1|polypeptide GalNAc transferase 1|polypeptide N-acetylgalactosaminyltransferase 1|pp-GaNTase 1|ppGaNTase-T1|protein-UDP acetylgalactosaminyltransferase 1
|
| Swissprots |
O08912 Q7TND1 Q5BKS3
|
| Accessions |
EDK96993 EDK96994 O08912 AK083391 AK085878 AK148550 BAE28617 BC038627 BC056215 AAH56215 BC090962 AAH90962 BY142456 BY711053 CX123572 U73820 AAB58477 XM_006525650 XP_006525713 NM_001160404 NP_001153876 NM_013814 NP_038842
|
| Function |
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. {ECO:0000269|PubMed:9153242}.
|
| Subcellular Location |
Polypeptide N- acetylgalactosaminyltransferase 1: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed at high level. Higher expression in kidney, heart, small intestine and cervix and to a lesser extent in all the other tissues tested. {ECO:0000269|PubMed:12651884, ECO:0000269|PubMed:9153242}.
|
| Top Pathways |
Mucin type O-Glycan biosynthesis
|