Gene Symbol | Galnt1 |
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Entrez Gene | 14423 |
Alt Symbol | - |
Species | Mouse |
Gene Type | protein-coding |
Description | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 |
Other Description | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1|galNAc-T1|polypeptide GalNAc transferase 1|polypeptide N-acetylgalactosaminyltransferase 1|pp-GaNTase 1|ppGaNTase-T1|protein-UDP acetylgalactosaminyltransferase 1 |
Swissprots | O08912 Q7TND1 Q5BKS3 |
Accessions | EDK96993 EDK96994 O08912 AK083391 AK085878 AK148550 BAE28617 BC038627 BC056215 AAH56215 BC090962 AAH90962 BY142456 BY711053 CX123572 U73820 AAB58477 XM_006525650 XP_006525713 NM_001160404 NP_001153876 NM_013814 NP_038842 |
Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. {ECO:0000269|PubMed:9153242}. |
Subcellular Location | Polypeptide N- acetylgalactosaminyltransferase 1: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Widely expressed at high level. Higher expression in kidney, heart, small intestine and cervix and to a lesser extent in all the other tissues tested. {ECO:0000269|PubMed:12651884, ECO:0000269|PubMed:9153242}. |
Top Pathways | Mucin type O-Glycan biosynthesis |
GalNAc-T1 CRISPR/Cas9 KO Plasmid (m) - sc-420476 from Santa Cruz Biotechnology
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GalNAc-T1 HDR Plasmid (m) - sc-420476-HDR from Santa Cruz Biotechnology
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GalNAc-T1 Double Nickase Plasmid (m) - sc-420476-NIC from Santa Cruz Biotechnology
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GalNAc-T1 Double Nickase Plasmid (m2) - sc-420476-NIC-2 from Santa Cruz Biotechnology
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GalNAc-T1 CRISPR Activation Plasmid (m) - sc-420476-ACT from Santa Cruz Biotechnology
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GalNAc-T1 CRISPR Activation Plasmid (m2) - sc-420476-ACT-2 from Santa Cruz Biotechnology
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GalNAc-T1 Lentiviral Activation Particles (m) - sc-420476-LAC from Santa Cruz Biotechnology
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GalNAc-T1 Lentiviral Activation Particles (m2) - sc-420476-LAC-2 from Santa Cruz Biotechnology
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GalNAc-T1 siRNA (m) - sc-75083 from Santa Cruz Biotechnology
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GalNAc-T1 shRNA Plasmid (m) - sc-75083-SH from Santa Cruz Biotechnology
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GalNAc-T1 shRNA (m) Lentiviral Particles - sc-75083-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU004041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN31699 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31699 from Sigma-Aldrich
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GALNT1 siRNA (Mouse) - CRM1483 from Cohesion Biosciences
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GALNT1 - MBS8200112 from MyBioSource
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shRNA set against Mouse GALNT1 (NM_013814.3) - SHH298961 from Creative biogene
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Mouse GALNT1 siRNA - orb280959 from Biorbyt
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GALNT1 shRNA Plasmid (Mouse) - CHM1483 from Cohesion Biosciences
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