RASSF5

Gene Symbol RASSF5
Entrez Gene 83593
Alt Symbol Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3
Species Human
Gene Type protein-coding
Description Ras association (RalGDS/AF-6) domain family member 5
Other Description Rap1-binding protein|Ras association (RalGDS/AF-6) domain family 5|Ras effector-like protein|new ras effector 1|novel Ras effector 1|ras association domain-containing protein 5|regulator for cell adhesion and polarization enriched in lymphoid tissue|tumor suppressor RASSF3
Swissprots Q8WXF4 Q5SY32 A8K1E6 Q8WWW0 Q9BT99 Q8WWV9
Accessions CAI15252 CAI15253 CAI15254 CAI15256 EAW93541 EAW93542 EAW93543 EAW93544 EAW93545 Q8WWW0 AB209145 BAD92382 AF445801 AAL38592 AK056568 AK074115 BAB84941 AK289861 BAF82550 AK291268 BAF83957 AK292039 BAF84728 AL832784 CAI46164 AY062002 AAL40388 AY062003 AAL40389 AY216268 AAO61668 AY261332 AAP83360 BC004270 AAH04270 BC007203 AAH07203 BC042651 AAH42651 CD367770 DA370470 DQ892961 ABM83887 DQ896208 ABM87207 EU831661 ACE87261 NM_182663 NP_872604 NM_182664 NP_872605 NM_182665 NP_872606 NM_031437
Function Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. {ECO:0000269|PubMed:12676952, ECO:0000269|PubMed:12845325, ECO:0000269|PubMed:15569673}.
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
Tissue Specificity Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors. {ECO:0000269|PubMed:11965544, ECO:0000269|PubMed:12676952}.
Top Pathways Leukocyte transendothelial migration, Non-small cell lung cancer, Rap1 signaling pathway

Nore1 (10F10) - sc-80017 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Nore1 (10F10): sc-80017. Western blot analysis of Nore1 expression in HEK293 (A) and A-431 (B) whole cell lysates.

RASSF5 (I-20) - sc-22713 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-NORE1 antibody - ab22770 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NORE1 antibody (ab22770) at 1 µg/mlLane 1 : HEK293 cell lysateLane 2 : Mouse brain lysateLane 3 : HEK293 cell lysate with Human NORE1 peptide (ab23380) at 1 µg/mlLane 4 : Mouse brain lysate with Human NORE1 peptide (ab23380) at 1 µg/mlLysates/proteins at 20 µg per lane.SecondaryAlexa fluor goat polyclonal to rabbit IgG at 1/10000 dilution

Anti-NORE1 antibody - ab200229 from Abcam

Prices $359.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-NORE1 antibody (ab200229) at 1/500 dilution + Mouse liver lysate

Anti-NORE1 antibody - ab33292 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NORE1 antibody [1A11] - ab118002 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A11
All lanes : Anti-NORE1 antibody [1A11] (ab118002) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNA Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY NORE1 cDNA Lysates/proteins at 5 µg per lane.

Anti-NORE1 antibody - C-terminal - ab170997 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-NORE1 antibody - C-terminal (ab170997) at 1 µg/ml + Mouse spleen lysate at 10 µg

Anti-RASSF5 / RAPL Antibody (clone 1A11) - LS-C172729 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A11
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RASSF5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RASSF5.

Anti-RASSF5 / RAPL Antibody (clone 1H2) - LS-C172730 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RASSF5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RASSF5.

Anti-RASSF5 / RAPL Antibody (aa313-329) - LS-C40721 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RASSF5 / RAPL Antibody (aa313-329) - LS-C53365 from LifeSpan Bioscience

Prices $445.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-RASSF5 / RAPL Antibody (aa313-329) - LS-C84216 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RASSF5 / RAPL Antibody - LS-C73673 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RASSF5 / RAPL Antibody - LS-C153066 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RASSF5 / RAPL Antibody (aa119-414) - LS-C152769 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
WB: HaCaT cell lysate was probed with anti- Nore1A, clone 10F10 (0.5g/ml). Arrow indicates Nore1A (~45/47kDa).

Anti-RASSF5 / RAPL Antibody (C-Terminus) - LS-C170318 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-RASSF5 / RAPL Antibody (clone 1C6) - LS-C172680 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C6
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RASSF5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RASSF5.

NORE1 Antibody - NB500-248 from Novus Biologicals

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NORE1 Antibody [NB500-248] - Analysis of NORE1 using this antibody at 1:1000 dilution on 293 T cell lysates overexpressed with NORE1.

RASSF3 Antibody - NBP1-89425 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NORE1 Antibody (1H2) - NBP2-03691 from Novus Biologicals

Prices $379.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H2
Western Blot: NORE1 Antibody (1H2) [NBP2-03691] HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NORE1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NORE1.

NORE1 Antibody - NBP2-19565 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NORE1 Antibody [NBP2-19565] - Sample (50 ug of whole cell lysate) A: Mouse Brain, 10% SDS PAGE gel, diluted at 1:1000.

NORE1 Antibody - H00083593-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

NORE1 Antibody - H00083593-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

NORE1 Antibody - H00083593-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: NORE1 Antibody [H00083593-D01P] - Analysis of RASSF5 expression in transfected 293T cell line by RASSF5 polyclonal antibody.Lane 1: RASSF5 transfected lysate(30.40 KDa).Lane 2: Non-transfected lysate.

NORE1 Antibody (5C2) - H00083593-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5C2
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