RASSF5

Gene Symbol	RASSF5
Entrez Gene	83593
Alt Symbol	Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3
Species	Human
Gene Type	protein-coding
Description	Ras association (RalGDS/AF-6) domain family member 5
Other Description	Rap1-binding protein|Ras association (RalGDS/AF-6) domain family 5|Ras effector-like protein|new ras effector 1|novel Ras effector 1|ras association domain-containing protein 5|regulator for cell adhesion and polarization enriched in lymphoid tissue|tumor suppressor RASSF3
Swissprots	Q8WXF4 Q5SY32 A8K1E6 Q8WWW0 Q9BT99 Q8WWV9
Accessions	CAI15252 CAI15253 CAI15254 CAI15256 EAW93541 EAW93542 EAW93543 EAW93544 EAW93545 Q8WWW0 AB209145 BAD92382 AF445801 AAL38592 AK056568 AK074115 BAB84941 AK289861 BAF82550 AK291268 BAF83957 AK292039 BAF84728 AL832784 CAI46164 AY062002 AAL40388 AY062003 AAL40389 AY216268 AAO61668 AY261332 AAP83360 BC004270 AAH04270 BC007203 AAH07203 BC042651 AAH42651 CD367770 DA370470 DQ892961 ABM83887 DQ896208 ABM87207 EU831661 ACE87261 NM_182663 NP_872604 NM_182664 NP_872605 NM_182665 NP_872606 NM_031437
Function	Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. {ECO:0000269|PubMed:12676952, ECO:0000269|PubMed:12845325, ECO:0000269|PubMed:15569673}.
Subcellular Location	Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
Tissue Specificity	Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors. {ECO:0000269|PubMed:11965544, ECO:0000269|PubMed:12676952}.
Top Pathways	Leukocyte transendothelial migration, Non-small cell lung cancer, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NORE1 full length protein - ab132178 from Abcam Category Protein Source Wheat germ Species Human

Human NORE1 peptide - ab23380 from Abcam Category Peptide

Human NORE1 protein fragment - ab90277 from Abcam Category Protein Source E. coli Species Human

RASSF3 Antibody Blocking Peptide - LS-E5353 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RASSF3 Antibody Blocking Peptide - LS-E26646 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RASSF5 / RAPL Antibody Blocking Peptide - LS-E21829 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RASSF3 Partial Recombinant Protein - H00283349-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RASSF3 Recombinant Protein - H00283349-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NORE1 Partial Recombinant Protein - H00083593-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human NORE1 Protein - H00083593-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RASSF3 Protein - NBP2-23398 from Novus Biologicals Category Protein Prices $309.00 Sizes 100 µg Species Human

NORE1-Antibody-C-term-Blocking-peptide - BP11698b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RASSF5 / NORE1 - H00083593-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RASSF5 / NORE1 - H00083593-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RASSF5 / NORE1 - H00083593-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RASSF5 / NORE1 - H00083593-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RASSF5 fusion protein - ag1033 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human RASSF5, GST-tagged - RASSF5-1071H from Creative Biomart Category Protein Source E. coli.

Recombinant Human RASSF5, His-tagged - RASSF5-29658TH from Creative Biomart Category Protein Source E. coli

Recombinant Human RASSF5 - RASSF5-29726TH from Creative Biomart Category Protein Source E. coli

Recombinant Human Ras association domain-containing protein 5(RASSF5) - CSB-YP819906HU CSB-EP819906HU CSB-BP819906HU CSB-MP819906HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RASSF5 Protein - abx164573 from Abbexa Category Protein Species Human, Mouse, Rat

RASSF5 / NORE1 (transcript variant 3) - TP303854 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Human RASSF3 protein - orb169167 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

RASSF3 Recombinant Protein Antigen - NBP1-89425PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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