| Gene Symbol |
RASSF5
|
| Entrez Gene |
83593
|
| Alt Symbol |
Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras association (RalGDS/AF-6) domain family member 5
|
| Other Description |
Rap1-binding protein|Ras association (RalGDS/AF-6) domain family 5|Ras effector-like protein|new ras effector 1|novel Ras effector 1|ras association domain-containing protein 5|regulator for cell adhesion and polarization enriched in lymphoid tissue|tumor suppressor RASSF3
|
| Swissprots |
Q8WXF4 Q5SY32 A8K1E6 Q8WWW0 Q9BT99 Q8WWV9
|
| Accessions |
CAI15252 CAI15253 CAI15254 CAI15256 EAW93541 EAW93542 EAW93543 EAW93544 EAW93545 Q8WWW0 AB209145 BAD92382 AF445801 AAL38592 AK056568 AK074115 BAB84941 AK289861 BAF82550 AK291268 BAF83957 AK292039 BAF84728 AL832784 CAI46164 AY062002 AAL40388 AY062003 AAL40389 AY216268 AAO61668 AY261332 AAP83360 BC004270 AAH04270 BC007203 AAH07203 BC042651 AAH42651 CD367770 DA370470 DQ892961 ABM83887 DQ896208 ABM87207 EU831661 ACE87261 NM_182663 NP_872604 NM_182664 NP_872605 NM_182665 NP_872606 NM_031437
|
| Function |
Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. {ECO:0000269|PubMed:12676952, ECO:0000269|PubMed:12845325, ECO:0000269|PubMed:15569673}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
|
| Tissue Specificity |
Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors. {ECO:0000269|PubMed:11965544, ECO:0000269|PubMed:12676952}.
|
| Top Pathways |
Leukocyte transendothelial migration, Non-small cell lung cancer, Rap1 signaling pathway
|