SHC2

Gene Symbol	SHC2
Entrez Gene	25759
Alt Symbol	SCK, SHCB, SLI
Species	Human
Gene Type	protein-coding
Description	SHC (Src homology 2 domain containing) transforming protein 2
Other Description	SH2 domain protein C2\|SHC-transforming protein 2\|SHC-transforming protein B\|neuronal Shc adaptor homolog\|protein Sck\|src homology 2 domain-containing-transforming protein C2
Swissprots	Q9UCX4 Q9NPL5 O60230 P98077
Accessions	P98077 AB001451 BAA25798 AL134433 AL360254 CAB96175 BC030527 BC034544 BC048290 BC156109 AAI56110 BC156898 AAI56899 BQ025513 BU754380 BY796046 CF457169 CK826553 XM_011527893 XP_011526195 XM_011527894 XP_011526196 XM_011527895 XP_011526197 XM_011527896 XP_011526198 NM_012435 NP_036567
Function	Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus. {ECO:0000269\|PubMed:9507002}.
Top Pathways	Focal adhesion, Natural killer cell mediated cytotoxicity, Estrogen signaling pathway, Chronic myeloid leukemia, Prolactin signaling pathway

Sck (M-90) - sc-33808 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Sck (M-90): sc-33808. Western blot analysis of Sck expression in HUV-EC-C whole cell lysate.

Sck (H-70) - sc-33807 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Sck (H-70): sc-33807. Western blot analysis of Sck expression in non-transfected: sc-117752 (A) and human Sck transfected: sc-372011 (B) 293T whole cell lysates.

Sck (P-20) - sc-25148 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Sck (P-20): sc-25148. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippocampus tissue showing cytoplasmic staining of neuronal cells.

Sck (S-20) - sc-25147 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Sck (S-20): sc-25147. Western blot analysis of Sck expression in Hep G2 (A), IMR-32 (B), MCF7 (C) and HUV-EC-C (D) whole cell lysates.

Sck (R12.1) - sc-100855 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

Sck (R12.1): sc-100855. Western blot analysis of Sck expression in IMR-32 whole cell lysate.

Anti-SHC2 antibody - ab57019 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-SHC2 antibody - C-terminal - ab174822 from Abcam

Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-SHC2 antibody - C-terminal (ab174822) at 1/1000 dilutionLane 1 : Mouse brain total cell extractsLane 2 : Jurkat total cell extractsLane 3 : Jurkat total cell extracts

Anti-SLI antibody - ab110461 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-SLI antibody (ab110461) at 1/500 dilutionLane 1 : Extracts from MCF7 cellsLane 2 : Extracts from HUVEC cellsLane 3 : Extracts from Jurkat cellsLane 4 : Extracts from Jurkat cells, with blocking peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-SHC2 / SLI Antibody (aa569-582) - LS-C132068 from LifeSpan Bioscience

Prices	$515.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-SHC2 / SLI Antibody (aa339-384) - LS-C313945 from LifeSpan Bioscience

Prices	$345.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SHC2 / SLI Antibody (aa261-310) - LS-C120393 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts from Jurkat cells, using SHC2 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-SHC2 / SLI Antibody (aa98-302) - LS-C296400 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

SHC2 Antibody - NBP1-87076 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: SHC2 Antibody [NBP1-87076] - Lane 1: Marker [kDa] 229, 112, 84, 48, 32, 27, 17. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted). Lane 5: Human liver tissue. Lane 6: Human tonsil tissue

SHC2 Antibody (4A4) - H00025759-M01 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	4A4

SHC2 Antibody - NB100-66326 from Novus Biologicals

Prices	$299.00
Sizes	50 µg
Host	Goat
Clonality	Polyclonal

SHC2 Antibody - H00025759-A01 from Novus Biologicals

Prices	$269.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

SHC2/Sck Polyclonal Antibody - bs-12144R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

SHC2/Sck Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12144R-A350 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

SHC2/Sck Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12144R-A488 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

SHC2/Sck Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12144R-A555 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

SHC2/Sck Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12144R-A647 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

SHC2/Sck Polyclonal Antibody, Cy3 Conjugated - bs-12144R-Cy3 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

SHC2/Sck Polyclonal Antibody, Cy5 Conjugated - bs-12144R-Cy5 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

SHC2/Sck Polyclonal Antibody, Cy5.5 Conjugated - bs-12144R-Cy5.5 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

SHC2/Sck Polyclonal Antibody, Cy7 Conjugated - bs-12144R-Cy7 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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