| Gene Symbol |
SHC2
|
| Entrez Gene |
25759
|
| Alt Symbol |
SCK, SHCB, SLI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SHC (Src homology 2 domain containing) transforming protein 2
|
| Other Description |
SH2 domain protein C2|SHC-transforming protein 2|SHC-transforming protein B|neuronal Shc adaptor homolog|protein Sck|src homology 2 domain-containing-transforming protein C2
|
| Swissprots |
Q9UCX4 Q9NPL5 O60230 P98077
|
| Accessions |
P98077 AB001451 BAA25798 AL134433 AL360254 CAB96175 BC030527 BC034544 BC048290 BC156109 AAI56110 BC156898 AAI56899 BQ025513 BU754380 BY796046 CF457169 CK826553 XM_011527893 XP_011526195 XM_011527894 XP_011526196 XM_011527895 XP_011526197 XM_011527896 XP_011526198 NM_012435 NP_036567
|
| Function |
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus. {ECO:0000269|PubMed:9507002}.
|
| Top Pathways |
Focal adhesion, Natural killer cell mediated cytotoxicity, Estrogen signaling pathway, Chronic myeloid leukemia, Prolactin signaling pathway
|