TP73

Gene Symbol TP73
Entrez Gene 7161
Alt Symbol P73
Species Human
Gene Type protein-coding
Description tumor protein p73
Other Description p53-like transcription factor|p53-related protein
Swissprots Q5TBV6 Q17RN8 O15351 Q8NHW9 O15350 B7Z8Z1 C9J521 B7Z9C1 B7Z7J4 Q5TBV5 Q9NTK8 Q8TDY6 Q8TDY5
Accessions AAC61887 AAD39696 AAL38007 BAB87246 EAW71463 EAW71464 EAW71465 EAW71466 EAW71467 EAW71468 O15350 AB055065 BAB87244 AB055066 BAB87245 AI094238 AK295669 BAH12150 AK302118 BAH13630 AK304177 BAH14127 AK304784 BAH14257 AK310432 AY040827 AAK81884 AY040828 AAK81885 AY040829 AAK81886 BC117251 AAI17252 BC117253 AAI17254 DA439168 DA446656 DC345760 HQ258345 ADR83099 Y11416 CAA72219 XM_011542064 XP_011540366 NM_001126240 NP_001119712 NM_001126241 NP_001119713 NM_001126242 NP_001119714 NM_001204184 NP_001191113 NM_001204185 NP_001191114 NM_001204186 NP_001191115 NM_001204187 NP_001191116 NM_001204188 NP_001191117 NM_001204189 NP_001191118 NM_001204190 NP_001191119 NM_001204191 NP_001191120 NM_001204192 NP_001191121 NM_005427 NP_005418
Function Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. {ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154}.
Subcellular Location Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage.
Tissue Specificity Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue. {ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:16461361}.
Top Pathways p53 signaling pathway, Neurotrophin signaling pathway, Measles, Hippo signaling pathway

SignalSilence® p73 siRNA - 6371 from Cell Signaling Technology

Category siRNA
Western blot analysis of extracts from HeLa cells untransfected (lane 1) or transfected with FLAG-p73 DNA (lanes 2 and 3). Overexpression of FLAG-p73 can be specifically blocked by co-transfection with p73 siRNA (lane 3). FLAG-p73 was detected using p73 Antibody #4662, and p42 was detected using p42 MAPK Antibody #9108. p73 Antibody confirms silencing of exogenous p73 expression, and the p42 MAPK Antibody is used to control for loading and siRNA specificity.

p73 CRISPR/Cas9 KO Plasmid (h) - sc-416822 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p73 HDR Plasmid (h) - sc-416822-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p73 Double Nickase Plasmid (h) - sc-416822-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p73 Double Nickase Plasmid (h2) - sc-416822-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p73 CRISPR Activation Plasmid (h) - sc-416822-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p73 CRISPR Activation Plasmid (h2) - sc-416822-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p73 Lentiviral Activation Particles (h) - sc-416822-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p73 Lentiviral Activation Particles (h2) - sc-416822-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p73 siRNA (h) - sc-36167 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p73 shRNA Plasmid (h) - sc-36167-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p73 shRNA (h) Lentiviral Particles - sc-36167-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p73 siRNA (h2) - sc-43730 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p73 shRNA Plasmid (h2) - sc-43730-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p73 shRNA (h2) Lentiviral Particles - sc-43730-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p73 RNAi - H00007161-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU140741 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2290 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2290 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00484 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00484

TP73 siRNA (Human) - CRH4912 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TP73 - MBS8204766 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TP73 (NM_005427.3) - SHH433152 from Creative biogene

Category siRNA
Species Reactivities Human

Human TP73 siRNA - orb265414 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TP73 shRNA Plasmid (Human) - CHH4912 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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