TP73

Gene Symbol TP73
Entrez Gene 7161
Alt Symbol P73
Species Human
Gene Type protein-coding
Description tumor protein p73
Other Description p53-like transcription factor|p53-related protein
Swissprots Q5TBV6 Q17RN8 O15351 Q8NHW9 O15350 B7Z8Z1 C9J521 B7Z9C1 B7Z7J4 Q5TBV5 Q9NTK8 Q8TDY6 Q8TDY5
Accessions AAC61887 AAD39696 AAL38007 BAB87246 EAW71463 EAW71464 EAW71465 EAW71466 EAW71467 EAW71468 O15350 AB055065 BAB87244 AB055066 BAB87245 AI094238 AK295669 BAH12150 AK302118 BAH13630 AK304177 BAH14127 AK304784 BAH14257 AK310432 AY040827 AAK81884 AY040828 AAK81885 AY040829 AAK81886 BC117251 AAI17252 BC117253 AAI17254 DA439168 DA446656 DC345760 HQ258345 ADR83099 Y11416 CAA72219 XM_011542064 XP_011540366 NM_001126240 NP_001119712 NM_001126241 NP_001119713 NM_001126242 NP_001119714 NM_001204184 NP_001191113 NM_001204185 NP_001191114 NM_001204186 NP_001191115 NM_001204187 NP_001191116 NM_001204188 NP_001191117 NM_001204189 NP_001191118 NM_001204190 NP_001191119 NM_001204191 NP_001191120 NM_001204192 NP_001191121 NM_005427 NP_005418
Function Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. {ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154}.
Subcellular Location Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage.
Tissue Specificity Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue. {ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:16461361}.
Top Pathways p53 signaling pathway, Neurotrophin signaling pathway, Measles, Hippo signaling pathway

Phospho-p73 (Tyr99) Antibody - 4665 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HT-1376 cells, untreated or pervanadate-treated ( 1 mM, 20 minutes), using Phospho-p73 (Tyr99) Antibody.

p73 (D3G10) Rabbit mAb - 14620 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3G10
Western blot analysis of MCF7 cells, untreated (-) or doxorubicin-treated (0.5 μM, 24 hr; +), using p73 (D3G10) Rabbit mAb (upper) and α-Actinin (D6F6) XP ® Rabbit mAb #6487 (lower).

p73 Antibody - 4662 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells untransfected (lane 1) or transfected with p73 DNA (lanes 2 and 3). Overexpression of p73 can be specifically blocked by co-transfection with p73 siRNA #6371 (lane 3). p73 was detected using p73 Antibody and p42 was detected using p42 MAPK Antibody #9108. The p73 Antibody confirms silencing of exogenous p73 expression and the p42 MAPK Antibody is used to control for loading and siRNA specificity.

ΔN p73 (N-16) - sc-23429 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ΔN p73 (4H223) - sc-70966 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

ΔN p73 (38C674) - sc-56086 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

p73 (S-20) - sc-9651 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p73 (S-20): sc-9651. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse kidney tissue showing nuclear localization.

p73 (N-19) - sc-7236 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p73 (H-79) - sc-7957 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p73 (H-79): sc-7957. Western blot analysis of p73 expression in HL-60 whole cell lysate.

p73 (E-4) - sc-17823 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p73 (E-4): sc-17823. Western blot analysis of p73 expression in SK-MEL-24 (A), K-562 (B), HL-60 (C) and COS (D) whole cell lysates.

p73 (C-20) - sc-7237 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p73 (5B429) - sc-56191 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

p73 (5B1288) - sc-56190 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

p73α (C-17) - sc-7238 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p73α (SPM431) - sc-56194 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal

p-p73 (Tyr 99) - sc-101769 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-p73 (Tyr 99): sc-101769. Western blot analysis of phosphorylated p73 expression in untreated (A) and vanadate-treated (B) K-562 whole cell lysates.

Anti-p73 (phospho Y99) antibody - ab38457 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-p73 (phospho Y99) antibody (ab38457) at 1/500 dilutionLane 1 : untreated extracts from K562 cellsLane 2 : Pervanadate treated extracts from K562 cellsLysates/proteins at 30 µg per lane.

Anti-p73 (phospho Y99) antibody - ab195749 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-p73 (phospho Y99) antibody (ab195749) at 1/500 dilutionLane 1 : Pervanadate treated K562 whole cell lysates with antigen-specific peptideLane 2 : Pervanadate treated K562 whole cell lysates

Anti-p73 alpha+beta antibody - ab31847 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-p73 alpha+beta antibody [ER-15] - ab17230 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone ER-15
Overlay histogram showing HEK293 cells stained with ab17230 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab17230, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HEK293 cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-p73 alpha+beta antibody [ER-15] - ab80701 from Abcam

Host Mouse
Clonality Monoclonal
Clone ER-15

Anti-p73 antibody - ab137797 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-p73 antibody (ab137797) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

Anti-p73 antibody - ab94554 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-p73 antibody (ab94554) at 1 µg/ml (in 5% skim milk / PBS buffer) + ACHN cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-p73 antibody - ab70093 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab70093, at 1/50 dilution, staining p73 in paraffin embedded human brain tissue by Immunohistochemistry in the absence or presence of the immunising peptide.

Anti-p73 antibody - ab39424 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab39424 staining human normal skin tissue. Staining is localised to nucleus.Left panel: with primary antibody at 2 ug/ml. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 antigen retrieval buffers EDTA pH 9.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 minutes and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.
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