| Gene Symbol | ITGA3 |
|---|---|
| Entrez Gene | 3675 |
| Alt Symbol | CD49C, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a |
| Species | Human |
| Gene Type | protein-coding |
| Description | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) |
| Other Description | CD49 antigen-like family member C|FRP-2|VLA-3 subunit alpha|antigen identified by monoclonal antibody J143|galactoprotein B3|integrin alpha-3|very late activation protein 3 receptor, alpha-3 subunit |
| Swissprots | A7E246 P26006 D3DTX4 B7ZM80 D3DTX5 B9EGQ1 |
| Accessions | EAW94645 EAW94646 EAW94647 EAW94648 P26006 AB209658 BAD92895 AK091950 AK092023 AK289961 BAF82650 AK293323 BAG56841 AK303384 BAG64440 BC015344 BC043917 AAH43917 BC136636 AAI36637 BC144328 AAI44329 BC150190 AAI50191 BM978115 D01038 BAA00845 DA655978 M59911 AAA36120 XM_005257308 XP_005257365 NM_002204 NP_002195 NM_005501 NP_005492 |
| Function | Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. {ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:15181153}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:15611341}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:15611341}; Lipid-anchor {ECO:0000269|PubMed:15611341}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, filopodium membrane {ECO:0000269|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Note=Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. {ECO:0000269|PubMed:10455171}. |
| Tissue Specificity | Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells. {ECO:0000269|PubMed:9111516}. |
| Top Pathways | PI3K-Akt signaling pathway, Focal adhesion, Dilated cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Hypertrophic cardiomyopathy (HCM) |