ITGA3

Gene Symbol ITGA3
Entrez Gene 3675
Alt Symbol CD49C, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a
Species Human
Gene Type protein-coding
Description integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Other Description CD49 antigen-like family member C|FRP-2|VLA-3 subunit alpha|antigen identified by monoclonal antibody J143|galactoprotein B3|integrin alpha-3|very late activation protein 3 receptor, alpha-3 subunit
Swissprots A7E246 P26006 D3DTX4 B7ZM80 D3DTX5 B9EGQ1
Accessions EAW94645 EAW94646 EAW94647 EAW94648 P26006 AB209658 BAD92895 AK091950 AK092023 AK289961 BAF82650 AK293323 BAG56841 AK303384 BAG64440 BC015344 BC043917 AAH43917 BC136636 AAI36637 BC144328 AAI44329 BC150190 AAI50191 BM978115 D01038 BAA00845 DA655978 M59911 AAA36120 XM_005257308 XP_005257365 NM_002204 NP_002195 NM_005501 NP_005492
Function Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. {ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:15181153}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:15611341}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:15611341}; Lipid-anchor {ECO:0000269|PubMed:15611341}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, filopodium membrane {ECO:0000269|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Note=Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. {ECO:0000269|PubMed:10455171}.
Tissue Specificity Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells. {ECO:0000269|PubMed:9111516}.
Top Pathways PI3K-Akt signaling pathway, Focal adhesion, Dilated cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Hypertrophic cardiomyopathy (HCM)

Integrin α3 CRISPR/Cas9 KO Plasmid (h) - sc-400841 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α3 HDR Plasmid (h) - sc-400841-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α3 Double Nickase Plasmid (h) - sc-400841-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α3 Double Nickase Plasmid (h2) - sc-400841-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α3 CRISPR Activation Plasmid (h) - sc-400841-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α3 CRISPR Activation Plasmid (h2) - sc-400841-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α3 Lentiviral Activation Particles (h) - sc-400841-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α3 Lentiviral Activation Particles (h2) - sc-400841-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α3 siRNA (h) - sc-35684 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Integrin α3 shRNA Plasmid (h) - sc-35684-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Integrin α3 shRNA (h) Lentiviral Particles - sc-35684-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Integrin αIII siRNA (h) - sc-63319 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Integrin αIII shRNA Plasmid (h) - sc-63319-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Integrin αIII shRNA (h) Lentiviral Particles - sc-63319-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Integrin alpha 3/CD49c RNAi - H00003675-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Integrin alpha 3/CD49c RNAi - H00003675-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU133981 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10808 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10808 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ITGA3 siRNA (Human) - CRH2466 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ITGA3 - MBS8219262 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ITGA3 (NM_002204.2) - SHH321185 from Creative biogene

Category siRNA
Species Reactivities Human

Human ITGA3 siRNA - orb262968 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ITGA3 shRNA Plasmid (Human) - CHH2466 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ITGA3 miRNA 3'UTR clone - MiUTR3H-07301 from Creative biogene

Species Reactivities Human
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