ITGA3

Gene Symbol	ITGA3
Entrez Gene	3675
Alt Symbol	CD49C, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a
Species	Human
Gene Type	protein-coding
Description	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Other Description	CD49 antigen-like family member C|FRP-2|VLA-3 subunit alpha|antigen identified by monoclonal antibody J143|galactoprotein B3|integrin alpha-3|very late activation protein 3 receptor, alpha-3 subunit
Swissprots	A7E246 P26006 D3DTX4 B7ZM80 D3DTX5 B9EGQ1
Accessions	EAW94645 EAW94646 EAW94647 EAW94648 P26006 AB209658 BAD92895 AK091950 AK092023 AK289961 BAF82650 AK293323 BAG56841 AK303384 BAG64440 BC015344 BC043917 AAH43917 BC136636 AAI36637 BC144328 AAI44329 BC150190 AAI50191 BM978115 D01038 BAA00845 DA655978 M59911 AAA36120 XM_005257308 XP_005257365 NM_002204 NP_002195 NM_005501 NP_005492
Function	Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. {ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:15181153}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:15611341}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:15611341}; Lipid-anchor {ECO:0000269|PubMed:15611341}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, filopodium membrane {ECO:0000269|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Note=Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. {ECO:0000269|PubMed:10455171}.
Tissue Specificity	Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells. {ECO:0000269|PubMed:9111516}.
Top Pathways	PI3K-Akt signaling pathway, Focal adhesion, Dilated cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Hypertrophic cardiomyopathy (HCM)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ITGA3 / CD49c Antibody Blocking Peptide - LS-E29339 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ITGA3 / CD49c Antibody Blocking Peptide - LS-E29338 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Integrin alpha 3 beta 1/VLA-3, CF - 2840-A3-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

SFRP2 protein (His tag) - 80R-3739 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

CD49c Blocking Peptide - abx062805 from Abbexa Category Peptide Species Human, Mouse

Integrin alpha-3 fusion protein - Ag17293 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Integrin alpha-3 fusion protein - ag15972 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Integrin Alpha 3 (ITGa3) - RPB289Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Integrin Alpha 3 (ITGa3) - RPB289Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

CD49c Blocking Peptide - CBP1611 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

Integrin α3 (F531) Peptide - BS3437P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Secreted Frizzled Related Protein 2 (SFRP2) - RPF879Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Integrin alpha-3(ITGA3) ,partial - CSB-YP011866HU CSB-EP011866HU CSB-BP011866HU CSB-MP011866HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Integrin alpha 3 beta 1/VLA-3 Protein, CF - 2840-A3 from R&D Systems Category Protein Prices $359.00 Sizes 50 µg Source Chinese Hamster Ovary cell line, CHO-derived Human Integrin alpha 3 (Phe33-Glu991) Accession # P26006 acidic tail Human Integrin beta 1 (Glu21-Asp728) Accession # P05556 basic tail N-terminus C-terminus Species Human

CD49c / ITGA3 (transcript variant b) - TP320975 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CD49c Blocking Peptide - abx162127 from Abbexa Category Peptide Species Human, Mouse

Integrin α3β1, Octyl-β-D-glucopyranoside Formulation, Human - CC1092 from EMD Millipore Prices $339.00 Sizes 25 µg Species Human

Integrin alpha 3/CD49c Recombinant Protein Antigen - NBP2-48514PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

ITGA3-Blocking-Peptide-C-term - BP21353b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ITGA3-Blocking-Peptide-N-term - BP21352a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ITGA3 Peptide, Human - M34GP07788H from Creative Peptides Category Peptide Source Synthetic. Species Human

CD49c Blocking Peptide - CBP4916 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

Recombinant Mouse Integrin alpha 3 beta 1/VLA-3 Protein, CF - 9374-A3 from R&D Systems Category Protein Prices $389.00 Sizes 50 µg Source Chinese Hamster Ovary cell line, CHO-derived Mouse Integrin alpha 3 (Phe33-Glu993) Accession # Q62470-1 His-Pro GGGSGGGS Acidic Tail 6-His tag Mouse Integrin beta 1 (Gln21-Asp728) Accession # P09055-1 His-Pro GGGSGGGS Basic Tail N-terminus C-terminus Species Mouse

Integrin Alpha 3, Recombinant Protein - MBS2033217 from MyBioSource Category Protein Prices $175.00, $375.00, $580.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

Integrin alpha-3 (ITGA3), partial, Recombinant Protein - MBS963361 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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