Gene Symbol | KDM3B |
---|---|
Entrez Gene | 51780 |
Alt Symbol | 5qNCA, C5orf7, JMJD1B, NET22 |
Species | Human |
Gene Type | protein-coding |
Description | lysine (K)-specific demethylase 3B |
Other Description | jmjC domain-containing histone demethylation protein 2B|jumonji domain containing 1B|jumonji domain-containing protein 1B|lysine-specific demethylase 3B|nuclear protein 5qNCA |
Swissprots | Q9NYF4 Q9BW93 A6H8X7 Q9BVH6 Q9UPS0 Q7LBC6 Q9BZ52 |
Accessions | EAW62141 EAW62142 Q7LBC6 AB029005 BAA83034 AF251039 AAF63765 AF338242 AAK13499 AK025755 AK304371 BAG65210 BC000539 AAH00539 BC001202 AAH01202 BC073869 BC117693 AAI17694 BC146788 AAI46789 BG390435 BI037147 BU149311 BU506660 BU752879 W28844 XM_005272018 XP_005272075 XM_011543488 XP_011541790 XM_011543489 XP_011541791 NM_016604 NP_057688 |
Function | Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Tissue Specificity | Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver. {ECO:0000269|PubMed:11087669, ECO:0000269|PubMed:11687974}. |