Gene Symbol | KDM3B |
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Entrez Gene | 51780 |
Alt Symbol | 5qNCA, C5orf7, JMJD1B, NET22 |
Species | Human |
Gene Type | protein-coding |
Description | lysine (K)-specific demethylase 3B |
Other Description | jmjC domain-containing histone demethylation protein 2B|jumonji domain containing 1B|jumonji domain-containing protein 1B|lysine-specific demethylase 3B|nuclear protein 5qNCA |
Swissprots | Q9NYF4 Q9BW93 A6H8X7 Q9BVH6 Q9UPS0 Q7LBC6 Q9BZ52 |
Accessions | EAW62141 EAW62142 Q7LBC6 AB029005 BAA83034 AF251039 AAF63765 AF338242 AAK13499 AK025755 AK304371 BAG65210 BC000539 AAH00539 BC001202 AAH01202 BC073869 BC117693 AAI17694 BC146788 AAI46789 BG390435 BI037147 BU149311 BU506660 BU752879 W28844 XM_005272018 XP_005272075 XM_011543488 XP_011541790 XM_011543489 XP_011541791 NM_016604 NP_057688 |
Function | Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. {ECO:0000269|PubMed:16603237}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Tissue Specificity | Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver. {ECO:0000269|PubMed:11087669, ECO:0000269|PubMed:11687974}. |
JMJD1B CRISPR/Cas9 KO Plasmid (h) - sc-404249 from Santa Cruz Biotechnology
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JMJD1B HDR Plasmid (h) - sc-404249-HDR from Santa Cruz Biotechnology
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JMJD1B Double Nickase Plasmid (h) - sc-404249-NIC from Santa Cruz Biotechnology
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JMJD1B Double Nickase Plasmid (h2) - sc-404249-NIC-2 from Santa Cruz Biotechnology
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JMJD1B CRISPR Activation Plasmid (h) - sc-404249-ACT from Santa Cruz Biotechnology
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JMJD1B CRISPR Activation Plasmid (h2) - sc-404249-ACT-2 from Santa Cruz Biotechnology
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JMJD1B Lentiviral Activation Particles (h) - sc-404249-LAC from Santa Cruz Biotechnology
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JMJD1B Lentiviral Activation Particles (h2) - sc-404249-LAC-2 from Santa Cruz Biotechnology
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JMJD1B siRNA (h) - sc-91707 from Santa Cruz Biotechnology
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JMJD1B shRNA Plasmid (h) - sc-91707-SH from Santa Cruz Biotechnology
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JMJD1B shRNA (h) Lentiviral Particles - sc-91707-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU142971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11029 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11029 from Sigma-Aldrich
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KDM3B siRNA (Human) - CRH9947 from Cohesion Biosciences
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shRNA set against Human KDM3B (NM_016604.3) - SHH324183 from Creative biogene
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shRNA set against Human JMJD1B(NM_016604.3) - SHL186060 from Creative biogene
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KDM3B shRNA Plasmid (Human) - CHH9947 from Cohesion Biosciences
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KDM3B miRNA 3'UTR clone - MiUTR1H-05065 from Creative biogene
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