ASIC1

Gene Symbol ASIC1
Entrez Gene 41
Alt Symbol ACCN2, ASIC, BNaC2
Species Human
Gene Type protein-coding
Description acid sensing (proton gated) ion channel 1
Other Description Cation channel, amiloride-sensitive, neuronal, 2|acid-sensing (proton-gated) ion channel 1|acid-sensing ion channel 1|acid-sensing ion channel 1a protein|amiloride-sensitive cation channel 2, neuronal|brain sodium channel 2
Swissprots P78349 E5KBL7 P78348 A3KN86 Q96CV2
Accessions EAW58116 EAW58117 EAW58118 EAW58119 P78348 AK290010 BAF82699 AK293960 BAG57332 AK311047 AW451342 BC013891 AAH13891 BC028722 BC133707 AAI33708 BM981170 DR003232 EU078959 ABU48925 HM991481 ADP44689 U78180 AAB48980 U78181 AAB48981 XM_011538350 XP_011536652 XM_011538351 XP_011536653 XM_011538352 XP_011536654 NM_001095 NP_001086 NM_001256830 NP_001243759 NM_020039 NP_064423 NR_046389
Function Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the cir
Subcellular Location Cell membrane {ECO:0000269|PubMed:12578970, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:22760635}; Multi- pass membrane protein {ECO:0000269|PubMed:12578970, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:22760635}. Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4 (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in most or all neurons.
Top Pathways Inflammatory mediator regulation of TRP channels

ASIC1 (H-70) - sc-28756 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ASIC1 (H-70): sc-28756. Western blot analysis of ASIC1 expression in U-87 MG whole cell lysate.

ASIC1 (E-15) - sc-13903 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ASIC1 (C-13) - sc-13910 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ASIC1 (N-18) - sc-13909 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ASIC1 (N-18): sc-13909. Western blot analysis of ASIC1 expression in IMR-32 (A), U-87 MG (B), HT-1080 (C), CCRF-CEM (D) and HEK293 (E) whole cell lysates.

ASIC1 (S-20) - sc-13905 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ASIC1 (S-20): sc-13905. Western blot analysis of ASIC1 expression in mouse brain tissue extract.

Anti-ACCN2 antibody - ab87514 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-ACCN2 antibody - ab65698 from Abcam

Host Rabbit
Clonality Polyclonal
Ab65698 staining Human frontal lateral cortex. Staining is localised to the cell membrane.Left panel: with primary antibody diluted 1:2000. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 antigen retrieval buffer citrate pH 6.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 minutes and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required

Anti-ACCN2 antibody - Extracellular domain - ab81058 from Abcam

Host Sheep
Clonality Polyclonal

Anti-ASIC1 / ACCN2 Antibody (N-Terminus) - LS-C11719 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-ASIC1 / ACCN2 Antibody (N-Terminus) - LS-C11720 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-ACCN2 / ASIC Antibody (Cytoplasmic Domain) - LS-C93913 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-ACCN2 / ASIC Antibody (Extracellular Domain) - LS-C93925 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal

Anti-ASIC1 / ACCN2 Antibody (aa100-150) - LS-C93911 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-ASIC1 / ACCN2 Antibody (aa460-526, clone S271-44) - LS-C209523 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S271-44

Anti-ASIC1 / ACCN2 Antibody (aa500-526, AP) - LS-C212579 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ASIC1 / ACCN2 Antibody (aa500-526, APC) - LS-C212580 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ASIC1 / ACCN2 Antibody (aa500-526, Biotin) - LS-C212581 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ASIC1 / ACCN2 Antibody (aa500-526, Azide-free, HRP) - LS-C212583 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ASIC1 / ACCN2 Antibody (aa500-526, FITC) - LS-C212582 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ASIC1 / ACCN2 Antibody (aa460-526, clone S271-44, Atto 390) - LS-C230048 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S271-44

Anti-ASIC1 / ACCN2 Antibody (aa500-526, PE) - LS-C212584 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ASIC1 / ACCN2 Antibody (aa460-526, clone S271-44, Atto 594) - LS-C230050 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S271-44

Anti-ASIC1 / ACCN2 Antibody (aa460-526, clone S271-44, Atto 565) - LS-C230049 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S271-44

Anti-ASIC1 / ACCN2 Antibody (N-Terminus) - LS-C145313 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ACCN2 antibody LS-C145313 Western blot of Mouse Heart lysate. Antibody concentration 1 ug/ml.

Anti-ASIC1 / ACCN2 Antibody (aa460-526, clone S271-44, Atto 680) - LS-C230053 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S271-44
Search more