| Gene Symbol | ASIC1 |
|---|---|
| Entrez Gene | 41 |
| Alt Symbol | ACCN2, ASIC, BNaC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | acid sensing (proton gated) ion channel 1 |
| Other Description | Cation channel, amiloride-sensitive, neuronal, 2|acid-sensing (proton-gated) ion channel 1|acid-sensing ion channel 1|acid-sensing ion channel 1a protein|amiloride-sensitive cation channel 2, neuronal|brain sodium channel 2 |
| Swissprots | P78349 E5KBL7 P78348 A3KN86 Q96CV2 |
| Accessions | EAW58116 EAW58117 EAW58118 EAW58119 P78348 AK290010 BAF82699 AK293960 BAG57332 AK311047 AW451342 BC013891 AAH13891 BC028722 BC133707 AAI33708 BM981170 DR003232 EU078959 ABU48925 HM991481 ADP44689 U78180 AAB48980 U78181 AAB48981 XM_011538350 XP_011536652 XM_011538351 XP_011536653 XM_011538352 XP_011536654 NM_001095 NP_001086 NM_001256830 NP_001243759 NM_020039 NP_064423 NR_046389 |
| Function | Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the cir |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:12578970, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:22760635}; Multi- pass membrane protein {ECO:0000269|PubMed:12578970, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:22760635}. Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4 (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in most or all neurons. |
| Top Pathways | Inflammatory mediator regulation of TRP channels |