ASIC1

Gene Symbol	ASIC1
Entrez Gene	41
Alt Symbol	ACCN2, ASIC, BNaC2
Species	Human
Gene Type	protein-coding
Description	acid sensing (proton gated) ion channel 1
Other Description	Cation channel, amiloride-sensitive, neuronal, 2|acid-sensing (proton-gated) ion channel 1|acid-sensing ion channel 1|acid-sensing ion channel 1a protein|amiloride-sensitive cation channel 2, neuronal|brain sodium channel 2
Swissprots	P78349 E5KBL7 P78348 A3KN86 Q96CV2
Accessions	EAW58116 EAW58117 EAW58118 EAW58119 P78348 AK290010 BAF82699 AK293960 BAG57332 AK311047 AW451342 BC013891 AAH13891 BC028722 BC133707 AAI33708 BM981170 DR003232 EU078959 ABU48925 HM991481 ADP44689 U78180 AAB48980 U78181 AAB48981 XM_011538350 XP_011536652 XM_011538351 XP_011536653 XM_011538352 XP_011536654 NM_001095 NP_001086 NM_001256830 NP_001243759 NM_020039 NP_064423 NR_046389
Function	Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the cir
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12578970, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:22760635}; Multi- pass membrane protein {ECO:0000269|PubMed:12578970, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:22760635}. Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4 (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in most or all neurons.
Top Pathways	Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ACCN2 full length protein - ab114681 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Human ACCN2 protein fragment - ab152165 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

ACCN2 / ASIC Antibody Blocking Peptide - LS-E12478 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ACCN2 / ASIC Antibody Blocking Peptide - LS-E10035 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ACCN2 Protein - H00000041-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ACCN2 Protein - H00000041-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ACCN2-Antibody-C-term-Blocking-Peptide - BP9270b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ACCN2 Blocking Peptide - 33R-5935 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ASIC1 / ACCN2 - H00000041-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ASIC1 / ACCN2 - H00000041-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ASIC1 / ACCN2 - H00000041-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ASIC1 / ACCN2 - H00000041-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Recombinant Human ASIC1, His-tagged - ASIC1-3071H from Creative Biomart Category Protein Source E. Coli or Yeast Species Human

Acid-sensing ion channel 1 (ASIC1) - MBS1196562 from MyBioSource Category Protein Prices $1,365.00, $1,820.00 Sizes 1 mg (E Coli Derived), 1 mg (Yeast Derived) Source E Coli or Yeast Species Helicobacter

Acid-sensing ion channel 1 (Asic1) - MBS968511 from MyBioSource Category Protein Prices $1,375.00, $1,835.00 Sizes 1 mg (E Coli Derived), 1 mg (Yeast Derived) Source E Coli or Yeast Species Human

ASIC1 / ACCN2 (transcript variant 2) - TP317623 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ASIC1 Blocking Peptide - CBP7418 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Chicken

ACCN2 Recombinant Protein Antigen - NBP2-58458PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ASIC1 peptide - orb382323 from Biorbyt Category Peptide Species Human, Mouse, Rat, Chicken

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