| Gene Symbol |
Themis
|
| Entrez Gene |
210757
|
| Alt Symbol |
E430004N04Rik, Gasp, Spot, Tsepa, thylex
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
thymocyte selection associated
|
| Other Description |
grb2-associating protein|protein THEMIS|signaling phosphoprotein specific for T cells|thymocyte selection pathway associated|thymocyte-expressed molecule involved in selection|thymus lymphocyte exclusively expressed
|
| Swissprots |
Q8C9S6 Q3UU76 Q3TEM0 Q059Y0 Q8BGW0 Q8BGP0
|
| Accessions |
EDL04823 EDL04824 EDL04825 Q8BGW0 AA967480 AB509340 BAH79575 AK040594 BAC30638 AK041386 BAC30927 AK041562 BAC30986 AK041622 BAC31008 AK088136 BAC40167 AK089077 BAC40738 AK138701 BAE23752 AK169558 BAE41228 BB638055 BC094898 BC125486 AAI25487 BC125488 AAI25489 XM_006512643 XP_006512706 XM_011243152 XP_011241454 XR_871437 NM_001305663 NP_001292592 NM_178666 NP_848781 NR_131208
|
| Function |
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. {ECO:0000269|PubMed:19597497, ECO:0000269|PubMed:19597498, ECO:0000269|PubMed:19597499, ECO:0000269|PubMed:19620281, ECO:0000269|PubMed:19805304}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Expressed in the thymus and to a lesser extent in the spleen but not detectable in non-lymphoid tissues. Highly expressed in thymocytes between the pre-T-cell antigen receptor (pre-TCR) and positive-selection checkpoints and expressed at low level in mature T-cells (at protein level). {ECO:0000269|PubMed:19597497, ECO:0000269|PubMed:19597498, ECO:0000269|PubMed:19597499, ECO:0000269|PubMed:19805304}.
|