Themis

Gene Symbol Themis
Entrez Gene 210757
Alt Symbol E430004N04Rik, Gasp, Spot, Tsepa, thylex
Species Mouse
Gene Type protein-coding
Description thymocyte selection associated
Other Description grb2-associating protein|protein THEMIS|signaling phosphoprotein specific for T cells|thymocyte selection pathway associated|thymocyte-expressed molecule involved in selection|thymus lymphocyte exclusively expressed
Swissprots Q8C9S6 Q3UU76 Q3TEM0 Q059Y0 Q8BGW0 Q8BGP0
Accessions EDL04823 EDL04824 EDL04825 Q8BGW0 AA967480 AB509340 BAH79575 AK040594 BAC30638 AK041386 BAC30927 AK041562 BAC30986 AK041622 BAC31008 AK088136 BAC40167 AK089077 BAC40738 AK138701 BAE23752 AK169558 BAE41228 BB638055 BC094898 BC125486 AAI25487 BC125488 AAI25489 XM_006512643 XP_006512706 XM_011243152 XP_011241454 XR_871437 NM_001305663 NP_001292592 NM_178666 NP_848781 NR_131208
Function Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. {ECO:0000269|PubMed:19597497, ECO:0000269|PubMed:19597498, ECO:0000269|PubMed:19597499, ECO:0000269|PubMed:19620281, ECO:0000269|PubMed:19805304}.
Subcellular Location Cytoplasm. Nucleus.
Tissue Specificity Expressed in the thymus and to a lesser extent in the spleen but not detectable in non-lymphoid tissues. Highly expressed in thymocytes between the pre-T-cell antigen receptor (pre-TCR) and positive-selection checkpoints and expressed at low level in mature T-cells (at protein level). {ECO:0000269|PubMed:19597497, ECO:0000269|PubMed:19597498, ECO:0000269|PubMed:19597499, ECO:0000269|PubMed:19805304}.

Themis (mouse) blocking peptide - GTX88179-PEP from GeneTex

Category Peptide
Prices $239.00
Sizes 100 μg
Species Mouse

Themis Peptide - AC21-2152-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

THEMIS Control Peptide - AP09874CP-N from Acris Antibodies

Category Peptide
Prices $235.00
Sizes 100 µg

Recombinant Mouse Protein THEMIS(Themis) - CSB-YP804787MO CSB-EP804787MO CSB-BP804787MO CSB-MP804787MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Themis, Peptide - MBS427247 from MyBioSource

Category Peptide
Prices $175.00
Sizes 100 µg
Species Mouse

Protein THEMIS (Themis), Recombinant Protein - MBS1322294 from MyBioSource

Category Protein
Prices $1,435.00, $1,435.00, $1,660.00, $1,660.00, $2,430.00, $2,430.00, $2,870.00, $2,870.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse
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