Themis

Gene Symbol Themis
Entrez Gene 210757
Alt Symbol E430004N04Rik, Gasp, Spot, Tsepa, thylex
Species Mouse
Gene Type protein-coding
Description thymocyte selection associated
Other Description grb2-associating protein|protein THEMIS|signaling phosphoprotein specific for T cells|thymocyte selection pathway associated|thymocyte-expressed molecule involved in selection|thymus lymphocyte exclusively expressed
Swissprots Q8C9S6 Q3UU76 Q3TEM0 Q059Y0 Q8BGW0 Q8BGP0
Accessions EDL04823 EDL04824 EDL04825 Q8BGW0 AA967480 AB509340 BAH79575 AK040594 BAC30638 AK041386 BAC30927 AK041562 BAC30986 AK041622 BAC31008 AK088136 BAC40167 AK089077 BAC40738 AK138701 BAE23752 AK169558 BAE41228 BB638055 BC094898 BC125486 AAI25487 BC125488 AAI25489 XM_006512643 XP_006512706 XM_011243152 XP_011241454 XR_871437 NM_001305663 NP_001292592 NM_178666 NP_848781 NR_131208
Function Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. {ECO:0000269|PubMed:19597497, ECO:0000269|PubMed:19597498, ECO:0000269|PubMed:19597499, ECO:0000269|PubMed:19620281, ECO:0000269|PubMed:19805304}.
Subcellular Location Cytoplasm. Nucleus.
Tissue Specificity Expressed in the thymus and to a lesser extent in the spleen but not detectable in non-lymphoid tissues. Highly expressed in thymocytes between the pre-T-cell antigen receptor (pre-TCR) and positive-selection checkpoints and expressed at low level in mature T-cells (at protein level). {ECO:0000269|PubMed:19597497, ECO:0000269|PubMed:19597498, ECO:0000269|PubMed:19597499, ECO:0000269|PubMed:19805304}.

Themis CRISPR/Cas9 KO Plasmid (m) - sc-431706 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Themis HDR Plasmid (m) - sc-431706-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Themis Double Nickase Plasmid (m) - sc-431706-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Themis Double Nickase Plasmid (m2) - sc-431706-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Themis CRISPR Activation Plasmid (m) - sc-431706-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Themis CRISPR Activation Plasmid (m2) - sc-431706-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Themis Lentiviral Activation Particles (m) - sc-431706-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Themis Lentiviral Activation Particles (m2) - sc-431706-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Themis siRNA (m) - sc-143258 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Themis shRNA Plasmid (m) - sc-143258-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Themis shRNA (m) Lentiviral Particles - sc-143258-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU014591 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN42802 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42802 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

THEMIS siRNA (Mouse) - CRN1698 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

THEMIS - MBS8230085 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse THEMIS (NM_178666.5) - SHH426864 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse E430004N04Rik(NM_178666.5) - SHH022187 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse THEMIS siRNA - orb291173 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

THEMIS shRNA Plasmid (Mouse) - CHN1698 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

THEMIS miRNA 3'UTR clone - MiUTR1M-04125 from Creative biogene

Species Reactivities Mouse
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