| Gene Symbol |
AFMID
|
| Entrez Gene |
125061
|
| Alt Symbol |
FKF, KF, KFA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
arylformamidase
|
| Other Description |
FKF|KFA|KFase|N-formylkynurenine formamidase|kynurenine formamidase|probable arylformamidase
|
| Swissprots |
Q63HM1 A2RUB3
|
| Accessions |
EAW89509 EAW89510 Q63HM1 BC020920 BC132824 AAI32825 BC142973 AAI42974 BX648442 CAH56149 EU832465 ACE87637 EU832546 ACE86948 HQ258157 ADR82911 XM_011524326 XP_011522628 XM_011524327 XP_011522629 XM_011524328 XP_011522630 XM_011524329 XP_011522631 XM_011524330 XP_011522632 XM_011524331 XP_011522633 XM_011524332 XP_011522634 XM_011524333 XP_011522635 XM_011524334 XP_011522636 XM_011524335 XP_011522637 XM_011524336 XP_011522638 XM_011524337 XP_011522639 XR_934369 NM_001010982 NP_001010982 NM_001145526 NP_001138998 NR_027083
|
| Function |
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. {ECO:0000255|HAMAP-Rule:MF_03014}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000255|HAMAP- Rule:MF_03014}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03014}. Note=Predominantly cytosolic. Some fraction is nuclear. {ECO:0000255|HAMAP-Rule:MF_03014}.
|
| Top Pathways |
Glyoxylate and dicarboxylate metabolism, Tryptophan metabolism
|
![Western Blot: AFMID Overexpression Lysate (Adult Normal) [NBP2-08777] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AFMID.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/15820_AFMID%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08777-img0001.jpg)