Gene Symbol | AFMID |
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Entrez Gene | 125061 |
Alt Symbol | FKF, KF, KFA |
Species | Human |
Gene Type | protein-coding |
Description | arylformamidase |
Other Description | FKF|KFA|KFase|N-formylkynurenine formamidase|kynurenine formamidase|probable arylformamidase |
Swissprots | Q63HM1 A2RUB3 |
Accessions | EAW89509 EAW89510 Q63HM1 BC020920 BC132824 AAI32825 BC142973 AAI42974 BX648442 CAH56149 EU832465 ACE87637 EU832546 ACE86948 HQ258157 ADR82911 XM_011524326 XP_011522628 XM_011524327 XP_011522629 XM_011524328 XP_011522630 XM_011524329 XP_011522631 XM_011524330 XP_011522632 XM_011524331 XP_011522633 XM_011524332 XP_011522634 XM_011524333 XP_011522635 XM_011524334 XP_011522636 XM_011524335 XP_011522637 XM_011524336 XP_011522638 XM_011524337 XP_011522639 XR_934369 NM_001010982 NP_001010982 NM_001145526 NP_001138998 NR_027083 |
Function | Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. {ECO:0000255|HAMAP-Rule:MF_03014}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000255|HAMAP- Rule:MF_03014}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03014}. Note=Predominantly cytosolic. Some fraction is nuclear. {ECO:0000255|HAMAP-Rule:MF_03014}. |
Top Pathways | Glyoxylate and dicarboxylate metabolism, Tryptophan metabolism |
AFMID CRISPR/Cas9 KO Plasmid (h) - sc-414235 from Santa Cruz Biotechnology
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AFMID HDR Plasmid (h) - sc-414235-HDR from Santa Cruz Biotechnology
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AFMID Double Nickase Plasmid (h) - sc-414235-NIC from Santa Cruz Biotechnology
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AFMID Double Nickase Plasmid (h2) - sc-414235-NIC-2 from Santa Cruz Biotechnology
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AFMID CRISPR Activation Plasmid (h) - sc-414235-ACT from Santa Cruz Biotechnology
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AFMID CRISPR Activation Plasmid (h2) - sc-414235-ACT-2 from Santa Cruz Biotechnology
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AFMID Lentiviral Activation Particles (h) - sc-414235-LAC from Santa Cruz Biotechnology
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AFMID Lentiviral Activation Particles (h2) - sc-414235-LAC-2 from Santa Cruz Biotechnology
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AFMID siRNA (h) - sc-93733 from Santa Cruz Biotechnology
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AFMID shRNA Plasmid (h) - sc-93733-SH from Santa Cruz Biotechnology
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AFMID shRNA (h) Lentiviral Particles - sc-93733-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU139111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2922 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2922 from Sigma-Aldrich
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AFMID siRNA (Human) - CRJ4803 from Cohesion Biosciences
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AFMID - MBS8212349 from MyBioSource
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shRNA set against Human Afmid (NM_001010982.4) - SHH233058 from Creative biogene
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Human AFMID siRNA - orb275304 from Biorbyt
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AFMID shRNA Plasmid (Human) - CHJ4803 from Cohesion Biosciences
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