Gene Symbol | WNT1 |
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Entrez Gene | 7471 |
Alt Symbol | BMND16, INT1, OI15 |
Species | Human |
Gene Type | protein-coding |
Description | wingless-type MMTV integration site family, member 1 |
Other Description | proto-oncogene Int-1 homolog|proto-oncogene Wnt-1|wingless-type MMTV integration site family, member 1 (oncogene INT1) |
Swissprots | Q5U0N2 P04628 |
Accessions | CAA26874 CAI38639 EAW58030 P04628 BC074798 AAH74798 BC074799 AAH74799 BT019429 AAV38236 NM_005430 NP_005421 |
Function | Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development. {ECO:0000269|PubMed:23499309}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix. |
Top Pathways | Proteoglycans in cancer, Wnt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Hippo signaling pathway, HTLV-I infection |
Wnt-1 CRISPR/Cas9 KO Plasmid (h) - sc-400982 from Santa Cruz Biotechnology
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Wnt-1 HDR Plasmid (h) - sc-400982-HDR from Santa Cruz Biotechnology
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Wnt-1 Double Nickase Plasmid (h) - sc-400982-NIC from Santa Cruz Biotechnology
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Wnt-1 Double Nickase Plasmid (h2) - sc-400982-NIC-2 from Santa Cruz Biotechnology
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Wnt-1 CRISPR Activation Plasmid (h) - sc-400982-ACT from Santa Cruz Biotechnology
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Wnt-1 CRISPR Activation Plasmid (h2) - sc-400982-ACT-2 from Santa Cruz Biotechnology
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Wnt-1 Lentiviral Activation Particles (h) - sc-400982-LAC from Santa Cruz Biotechnology
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Wnt-1 Lentiviral Activation Particles (h2) - sc-400982-LAC-2 from Santa Cruz Biotechnology
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Wnt-1 siRNA (h) - sc-36839 from Santa Cruz Biotechnology
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Wnt-1 shRNA Plasmid (h) - sc-36839-SH from Santa Cruz Biotechnology
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Wnt-1 shRNA (h) Lentiviral Particles - sc-36839-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN22911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22911 from Sigma-Aldrich
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WNT1 siRNA (Human) - CRH5110 from Cohesion Biosciences
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WNT1 - MBS8237386 from MyBioSource
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shRNA set against Human WNT1 (NM_005430.3) - SHH447196 from Creative biogene
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Wnt-1 CRISPR/Cas9 KO Plasmid (h2) - sc-400982-KO-2 from Santa Cruz Biotechnology
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Wnt-1 HDR Plasmid (h2) - sc-400982-HDR-2 from Santa Cruz Biotechnology
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WNT1 shRNA Plasmid (Human) - CHH5110 from Cohesion Biosciences
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WNT1 miRNA 3'UTR clone - MiUTR1H-11275 from Creative biogene
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