| Gene Symbol |
RHOU
|
| Entrez Gene |
58480
|
| Alt Symbol |
ARHU, CDC42L1, G28K, WRCH1, hG28K
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ras homolog family member U
|
| Other Description |
2310026M05Rik|CDC42-like GTPase 1|GTP-binding protein SB128|GTP-binding protein like 1|Ryu GTPase|ras homolog gene family, member U|ras-like gene family member U|rho GTPase-like protein ARHU|rho-related GTP-binding protein RhoU|wnt-1 responsive Cdc42 homolog 1
|
| Swissprots |
Q8TDQ2 Q59FE9 Q7L0Q8 B1AKN1
|
| Accessions |
ABD48870 ABD48871 ABD48872 ABD48873 ABD48874 ABD48875 CAY55989 CBX47521 EAW69885 EAW69886 Q7L0Q8 AB051826 BAB18638 AB074878 BAB86361 AB209511 BAD92748 AF211836 AAL54874 AF251701 AAL99390 AF282258 AAG46058 AF378087 AAK83340 AI094830 AK001478 AK289971 BAF82660 BC040076 AAH40076 DA321957 NM_021205 NP_067028 NR_037962
|
| Function |
Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:11459829, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:21834987}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}; Lipid- anchor {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}; Cytoplasmic side {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. Golgi apparatus membrane {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}; Lipid-anchor {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. Cell junction, focal adhesion {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. Cell projection, podosome {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}. Note=Localizes to podosomes in SRC- transformed cells. {ECO:0000269|PubMed:16046391, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058}.
|
| Tissue Specificity |
Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta. {ECO:0000269|PubMed:11459829, ECO:0000269|PubMed:14731133}.
|