| Gene Symbol |
IFIT3
|
| Entrez Gene |
3437
|
| Alt Symbol |
CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interferon-induced protein with tetratricopeptide repeats 3
|
| Other Description |
CIG49|IFI-60K|IFIT-3|IFIT-4|ISG-60|interferon-induced 60 kDa protein|interferon-induced protein with tetratricopeptide repeats 4|retinoic acid-induced gene G protein
|
| Swissprots |
O14879 Q99634 Q9BSK7
|
| Accessions |
AAC34669 EAW50143 EAW50144 O14879 AF026939 AAB95160 AF026943 AF083470 AAC63524 AK290427 BAF83116 AK297137 BAG59639 AK312675 BC001383 AAH01383 BC004977 AAH04977 BM790031 BT007284 AAP35948 BU509201 BX101054 DA081546 DA160435 DA673951 DB268497 JF432276 ADZ15493 U52513 AAB40606 NM_001031683 NP_001026853 NM_001289758 NP_001276687 NM_001289759 NP_001276688 NM_001549 NP_001540
|
| Function |
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20686046, ECO:0000269|PubMed
|
| Subcellular Location |
Cytoplasm. Mitochondrion.
|
| Tissue Specificity |
Expression significantly higher in peripheral blood mononuclear cells (PBMCs) and monocytes from systemic lupus erythematosus (SLE) patients than in those from healthy individuals (at protein level). Spleen, lung, leukocytes, lymph nodes, placenta, bone marrow and fetal liver. {ECO:0000269|PubMed:18706081}.
|
![Western Blot: IFIT3 Overexpression Lysate (Adult Normal) [NBL1-11837] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IFIT3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6865_IFIT3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11837-img0002.jpg)
![Western Blot: IFIT3 Overexpression Lysate (Adult Normal) [NBL1-11836] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IFIT3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3850_IFIT3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11836-img0002.jpg)