IFIT3

Gene Symbol	IFIT3
Entrez Gene	3437
Alt Symbol	CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G
Species	Human
Gene Type	protein-coding
Description	interferon-induced protein with tetratricopeptide repeats 3
Other Description	CIG49|IFI-60K|IFIT-3|IFIT-4|ISG-60|interferon-induced 60 kDa protein|interferon-induced protein with tetratricopeptide repeats 4|retinoic acid-induced gene G protein
Swissprots	O14879 Q99634 Q9BSK7
Accessions	AAC34669 EAW50143 EAW50144 O14879 AF026939 AAB95160 AF026943 AF083470 AAC63524 AK290427 BAF83116 AK297137 BAG59639 AK312675 BC001383 AAH01383 BC004977 AAH04977 BM790031 BT007284 AAP35948 BU509201 BX101054 DA081546 DA160435 DA673951 DB268497 JF432276 ADZ15493 U52513 AAB40606 NM_001031683 NP_001026853 NM_001289758 NP_001276687 NM_001289759 NP_001276688 NM_001549 NP_001540
Function	IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20686046, ECO:0000269|PubMed
Subcellular Location	Cytoplasm. Mitochondrion.
Tissue Specificity	Expression significantly higher in peripheral blood mononuclear cells (PBMCs) and monocytes from systemic lupus erythematosus (SLE) patients than in those from healthy individuals (at protein level). Spleen, lung, leukocytes, lymph nodes, placenta, bone marrow and fetal liver. {ECO:0000269|PubMed:18706081}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IFIT3 full length protein - ab152469 from Abcam Category Protein Source Wheat germ Species Human

Human IFIT3 full length protein - ab201888 from Abcam Category Protein Source E. coli Species Human

IFIT3 Partial Recombinant Protein - H00003437-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

IFIT3 Recombinant Protein - H00003437-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Human IFIT3 protein - orb244290 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

IFIT3 Blocking Peptide - 33R-1568 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

IFIT3 protein - 80R-4252 from Fitzgerald Category Protein Prices $295.00 Sizes 100 µg Source E.coli

IFI60 / IFIT3 (1-490, His-tag) - AR51934PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

IFI60 / IFIT3 (1-490, His-tag) - AR51934PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

IFI60 / IFIT3 - H00003437-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

IFI60 / IFIT3 - H00003437-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

IFI60 / IFIT3 - H00003437-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

IFI60 / IFIT3 - H00003437-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

IFIT3 Peptide - 7759P from ProSci Category Peptide Species Human

IFIT3 fusion protein - Ag7349 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

IFIT3 fusion protein - Ag7518 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human IFIT3, GST-tagged - IFIT3-14069H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human IFIT3, His-tagged - IFIT3-94H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Interferon-induced protein with tetratricopeptide repeats 3(IFIT3) - CSB-YP011022HU CSB-BP011022HU CSB-MP011022HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Interferon-induced protein with tetratricopeptide repeats 3 - CSB-EP011022HU from Cusabio Category Protein Source E.coli Species Human

IFIT3, 1-490aa, Human, His tag, E.coli - ATGP3114 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

IFI60 / IFIT3 (transcript variant 1) - TP300610 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

IFI60 / IFIT3 (transcript variant 2) - TP314701 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

IFIT3 Protein - NBP2-32500PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

IFIT3 Peptide, Human - M34GP07428H from Creative Peptides Category Peptide Source Synthetic. Species Human

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