CTH

Gene Symbol CTH
Entrez Gene 1491
Alt Symbol -
Species Human
Gene Type protein-coding
Description cystathionine gamma-lyase
Other Description cystathionase (cystathionine gamma-lyase)|cysteine desulfhydrase|cysteine-protein sulfhydrase|gamma-cystathionase|homoserine deaminase|homoserine dehydratase
Swissprots Q53Y79 E9PDV0 P32929 Q9H4W7 Q53FB3 Q9H4W8 B4E1R2
Accessions EAX06450 EAX06451 P32929 AK223376 BAD97096 AK303946 BAG64874 AK310269 BC015807 AAH15807 BT006882 AAP35528 DB466459 EU832313 ACE87570 EU832398 ACE86883 S52028 AAB24699 S52784 AAB24700 XM_005270509 XP_005270566 XM_011540787 XP_011539089 NM_001190463 NP_001177392 NM_001902 NP_001893 NM_153742 NP_714964
Function Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. {ECO:0000269|PubMed:19019829, ECO:0000269|PubMed:19261609, ECO:0000269|PubMed:22169477}.
Subcellular Location Cytoplasm.
Top Pathways Glycine, serine and threonine metabolism, Cysteine and methionine metabolism, Selenocompound metabolism, Biosynthesis of amino acids

CTH-Over-expression-Lysate - LY12452a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag CTH (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CTH gene

CTH 293T Cell Transient Overexpression Lysate(Denatured) - H00001491-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

CTH HEK293 Cell Transient Overexpression Lysate (Non-Denatured) - L054T6 from Acris Antibodies

Category Cell Lysate
Prices $290.00
Sizes 100 µg

CTH overexpression lysate - LY419669 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

CTH overexpression lysate - LY434190 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

CTH 293 Cell Lysate - 409209 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Cystathionase Overexpression Lysate (Denatured) - H00001491-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
Western Blot: Cystathionase Overexpression Lysate (Denatured) [H00001491-T01] - Lane 1: CTH transfected lysate (44.66 KDa) Lane 2: Non-transfected lysate.

Cystathionase Overexpression Lysate (Native) - NBL1-09573 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Cystathionase Overexpression Lysate (Adult Normal) [NBL1-09573] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cystathionase.

CTH (h): 293 Lysate - sc-112203 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

CTH Over-expression Lysate Product - GWB-B59F34 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human CTH Knockdown Stable Cell Line - CSC-DC003794 from Creative biogene

Category Cell Line
Species Human
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