CTH

Gene Symbol	CTH
Entrez Gene	1491
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	cystathionine gamma-lyase
Other Description	cystathionase (cystathionine gamma-lyase)|cysteine desulfhydrase|cysteine-protein sulfhydrase|gamma-cystathionase|homoserine deaminase|homoserine dehydratase
Swissprots	Q53Y79 E9PDV0 P32929 Q9H4W7 Q53FB3 Q9H4W8 B4E1R2
Accessions	EAX06450 EAX06451 P32929 AK223376 BAD97096 AK303946 BAG64874 AK310269 BC015807 AAH15807 BT006882 AAP35528 DB466459 EU832313 ACE87570 EU832398 ACE86883 S52028 AAB24699 S52784 AAB24700 XM_005270509 XP_005270566 XM_011540787 XP_011539089 NM_001190463 NP_001177392 NM_001902 NP_001893 NM_153742 NP_714964
Function	Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. {ECO:0000269|PubMed:19019829, ECO:0000269|PubMed:19261609, ECO:0000269|PubMed:22169477}.
Subcellular Location	Cytoplasm.
Top Pathways	Glycine, serine and threonine metabolism, Cysteine and methionine metabolism, Selenocompound metabolism, Biosynthesis of amino acids

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cystathionase peptide - ab183695 from Abcam Category Peptide Prices $181.00 Sizes 1 mg

Cystathionase peptide - ab139491 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human Cystathionase full length protein - ab114582 from Abcam Category Protein Source Wheat germ Species Human

Human Cystathionase full length protein - ab123201 from Abcam Category Protein Source E. coli Species Human

CTH Antibody Blocking Peptide - LS-E16786 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Cystathionase Protein - H00001491-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Cystathionase Protein - NBP1-78832 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human CTH protein - orb168173 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human Cystathionine gamma-lyase R protein - orb163497 from Biorbyt Category Protein Prices $306.00, $451.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E. coli Species Human

CTH protein (His tag) - 80R-2075 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

CTH Blocking Peptide - abx161071 from Abbexa Category Peptide Species Human, Mouse, Rat

Human CSE Protein - abx066229 from Abbexa Category Protein Source E.coli Species Human

CTH (1-405, His-tag) - AR50158PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

CTH (1-405, His-tag) - AR50158PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

CTH - H00001491-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CTH - H00001491-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CTH, 1-405aa, Human, His tag, E.coli - 01-P1333 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

CTH, Human, Recombinant - 19-CF60 from ARP American Research Products Category Protein Prices $119.00 Sizes 10 µg Source E. coli Species Human

CSE fusion protein - Ag2872 from Proteintech Group Category Protein Species Human

Recombinant Human CTH Enzyme - BP002562-CF60 from Syd Labs Category Protein Prices $98.00, $342.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human CTH Enzyme - BP002562-ENZ-212 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

CTH, 1-405aa, Recombinant Protein - GWB-P0705C from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human Cystathionase (cystathionine gamma-lyase), His-tagged - CTH-1333H from Creative Biomart Category Protein

Recombinant Human CTH - CTH-1334H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human CTH, MYC/DDK-tagged - CTH-1335H from Creative Biomart Category Protein Source HEK293 cells Species Human

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