CTH

Gene Symbol CTH
Entrez Gene 1491
Alt Symbol -
Species Human
Gene Type protein-coding
Description cystathionine gamma-lyase
Other Description cystathionase (cystathionine gamma-lyase)|cysteine desulfhydrase|cysteine-protein sulfhydrase|gamma-cystathionase|homoserine deaminase|homoserine dehydratase
Swissprots Q53Y79 E9PDV0 P32929 Q9H4W7 Q53FB3 Q9H4W8 B4E1R2
Accessions EAX06450 EAX06451 P32929 AK223376 BAD97096 AK303946 BAG64874 AK310269 BC015807 AAH15807 BT006882 AAP35528 DB466459 EU832313 ACE87570 EU832398 ACE86883 S52028 AAB24699 S52784 AAB24700 XM_005270509 XP_005270566 XM_011540787 XP_011539089 NM_001190463 NP_001177392 NM_001902 NP_001893 NM_153742 NP_714964
Function Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. {ECO:0000269|PubMed:19019829, ECO:0000269|PubMed:19261609, ECO:0000269|PubMed:22169477}.
Subcellular Location Cytoplasm.
Top Pathways Glycine, serine and threonine metabolism, Cysteine and methionine metabolism, Selenocompound metabolism, Biosynthesis of amino acids

CTH (A-2) - sc-365381 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CTH (A-2): sc-365381. Western blot analysis of CTH expression in non-transfected 293T: sc-117752 (A), mouse CTH transfected 293T: sc-119499 (B), K-562 (C) and HeLa (D) whole cell lysates.

CTH (D-12) - sc-365382 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CTH (D-12): sc-365382. Western blot analysis of CTH expression in non-transfected: sc-117752 (A) and mouse CTH transfected: sc-119499 (B) 293T whole cell lysates.

CTH (H-167) - sc-135203 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CTH (H-167): sc-135203. Western blot analysis of CTH expression in non-transfected: sc-117752 (A) and mouse CTH transfected: sc-119499 (B) 293T whole cell lysates.

CTH (F-1) - sc-374249 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CTH (F-1): sc-374249. Western blot analysis of CTH expression in 293T (A) and Hep G2 (B) whole cell lysates.

CTH (P-15) - sc-131905 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CTH (P-15): sc-131905. Western blot analysis of CTH expression in non-transfected: sc-117752 (A) and mouse CTH transfected: sc-119499 (B) 293T whole cell lysates.

CTH (K-20) - sc-101924 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
CTH (K-20): sc-101924. Western blot analysis of CTH expression in Hep G2 whole cell lysate.

Anti-Cystathionase antibody - ab54573 from Abcam

Prices $390.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Cystathionase antibody (ab54573) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human colon.

Anti-Cystathionase antibody - ab136604 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab136604 stained MCF-7 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab136604 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Cystathionase antibody - ab80643 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Cystathionase antibody (ab80643) at 1 µg/ml + transfected 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Cystathionase antibody - ab131052 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemical analysis of SMMC Cells labelled with ab131052 at 1 µg/ml.

Anti-Cystathionase antibody - ab151769 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cystathionase antibody (ab151769) at 1/1000 dilutionLane 1 : HeLa whole cell lysateLane 2 : MOLT4 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Cystathionase antibody - ab125210 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Cystathionase antibody [EPR15468] - N-terminal - ab189916 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15468
All lanes : Anti-Cystathionase antibody [EPR15468] - N-terminal (ab189916) at 1/10000 dilutionLane 1 : HeLa cell lysateLane 2 : K562 cell lysateLysates/proteins at 20 µg per lane.

Anti-CTH Antibody (clone 1E12) - LS-C337259 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 1E12
IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-CTH mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-CTH Antibody (aa14-224, Biotin) - LS-C299533 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTH Antibody (aa14-224, FITC) - LS-C303889 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTH Antibody (aa163-382, FITC) - LS-C304334 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTH Antibody (aa38-87) - LS-C80809 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-CTH Antibody - LS-C307120 from LifeSpan Bioscience

Host Mouse
Clonality Polyclonal

Anti-CTH Antibody - LS-C310020 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTH Antibody (aa163-382, Biotin) - LS-C305700 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTH Antibody - LS-C311067 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTH Antibody (aa281-330) - LS-C80810 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CTH antibody LS-C80810 was used in IHC to stain formalin-fixed, paraffin-embedded human heart.

Anti-CTH Antibody (aa1-406, Azide-free) - LS-C327146 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CTH Antibody - LS-C341925 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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