| Gene Symbol |
RHOG
|
| Entrez Gene |
391
|
| Alt Symbol |
ARHG
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ras homolog family member G
|
| Other Description |
ras homolog gene family, member G (rho G)|rho-related GTP-binding protein RhoG
|
| Swissprots |
P35238 Q8NI04 P84095
|
| Accessions |
EAX02575 EAX02576 EAX02577 P84095 AA424888 AF498974 AAM21121 AY563952 AAS75333 BC104177 AAI04178 BC104178 AAI04179 BI196968 BT019872 AAV38675 BX359696 CB125569 CR450335 CAG29331 CR542105 CAG46902 L11317 AAA60268 X61587 CAA43784 XM_005252916 XP_005252973 NM_001665 NP_001656
|
| Function |
Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:20679435}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
|
| Top Pathways |
Bacterial invasion of epithelial cells, Salmonella infection
|
