Gene Symbol | RHOG |
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Entrez Gene | 391 |
Alt Symbol | ARHG |
Species | Human |
Gene Type | protein-coding |
Description | ras homolog family member G |
Other Description | ras homolog gene family, member G (rho G)|rho-related GTP-binding protein RhoG |
Swissprots | P35238 Q8NI04 P84095 |
Accessions | EAX02575 EAX02576 EAX02577 P84095 AA424888 AF498974 AAM21121 AY563952 AAS75333 BC104177 AAI04178 BC104178 AAI04179 BI196968 BT019872 AAV38675 BX359696 CB125569 CR450335 CAG29331 CR542105 CAG46902 L11317 AAA60268 X61587 CAA43784 XM_005252916 XP_005252973 NM_001665 NP_001656 |
Function | Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:20679435}. |
Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. |
Top Pathways | Bacterial invasion of epithelial cells, Salmonella infection |
Rho G CRISPR/Cas9 KO Plasmid (h) - sc-402608 from Santa Cruz Biotechnology
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Rho G HDR Plasmid (h) - sc-402608-HDR from Santa Cruz Biotechnology
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Rho G Double Nickase Plasmid (h) - sc-402608-NIC from Santa Cruz Biotechnology
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Rho G Double Nickase Plasmid (h2) - sc-402608-NIC-2 from Santa Cruz Biotechnology
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Rho G CRISPR Activation Plasmid (h) - sc-402608-ACT from Santa Cruz Biotechnology
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Rho G CRISPR Activation Plasmid (h2) - sc-402608-ACT-2 from Santa Cruz Biotechnology
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Rho G Lentiviral Activation Particles (h) - sc-402608-LAC from Santa Cruz Biotechnology
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Rho G Lentiviral Activation Particles (h2) - sc-402608-LAC-2 from Santa Cruz Biotechnology
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Rho G siRNA (h) - sc-41889 from Santa Cruz Biotechnology
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Rho G shRNA Plasmid (h) - sc-41889-SH from Santa Cruz Biotechnology
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Rho G shRNA (h) Lentiviral Particles - sc-41889-V from Santa Cruz Biotechnology
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RhoG RNAi - H00000391-R01 from Novus Biologicals
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MISSION® esiRNA - EHU120671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18257 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18257 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05050 from Sigma-Aldrich
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RHOG siRNA (Human) - CRH0280 from Cohesion Biosciences
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RHOG - MBS8215595 from MyBioSource
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shRNA set against Human RHOG (NM_001665.3) - SHH395356 from Creative biogene
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shRNA set against Human RHOG(NM_001665.3) - SHR180924 from Creative biogene
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Human RHOG siRNA - orb260782 from Biorbyt
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RHOG shRNA Plasmid (Human) - CHH0280 from Cohesion Biosciences
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RHOG miRNA 3'UTR clone - MiUTR1H-08814 from Creative biogene
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