| Gene Symbol | DTX4 |
|---|---|
| Entrez Gene | 23220 |
| Alt Symbol | RNF155 |
| Species | Human |
| Gene Type | protein-coding |
| Description | deltex 4, E3 ubiquitin ligase |
| Other Description | E3 ubiquitin-protein ligase DTX4|RING finger protein 155|deltex 4 homolog|deltex homolog 4|deltex4|protein deltex-4 |
| Swissprots | Q0VF38 Q9Y2E6 |
| Accessions | EAW73838 Q9Y2E6 AB023154 BAA76781 AF086290 BC015592 BC119011 AAI19012 BC122861 AAI22862 BF195769 XM_006718483 XP_006718546 NM_001300727 NP_001287656 NM_015177 NP_055992 |
| Function | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. {ECO:0000250, ECO:0000269|PubMed:22388039}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Top Pathways | Notch signaling pathway |