Gene Symbol | DTX4 |
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Entrez Gene | 23220 |
Alt Symbol | RNF155 |
Species | Human |
Gene Type | protein-coding |
Description | deltex 4, E3 ubiquitin ligase |
Other Description | E3 ubiquitin-protein ligase DTX4|RING finger protein 155|deltex 4 homolog|deltex homolog 4|deltex4|protein deltex-4 |
Swissprots | Q0VF38 Q9Y2E6 |
Accessions | EAW73838 Q9Y2E6 AB023154 BAA76781 AF086290 BC015592 BC119011 AAI19012 BC122861 AAI22862 BF195769 XM_006718483 XP_006718546 NM_001300727 NP_001287656 NM_015177 NP_055992 |
Function | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. {ECO:0000250, ECO:0000269|PubMed:22388039}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Top Pathways | Notch signaling pathway |
Deltex-4 CRISPR/Cas9 KO Plasmid (h) - sc-411695 from Santa Cruz Biotechnology
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Deltex-4 HDR Plasmid (h) - sc-411695-HDR from Santa Cruz Biotechnology
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Deltex-4 Double Nickase Plasmid (h) - sc-411695-NIC from Santa Cruz Biotechnology
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Deltex-4 Double Nickase Plasmid (h2) - sc-411695-NIC-2 from Santa Cruz Biotechnology
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Deltex-4 CRISPR Activation Plasmid (h) - sc-411695-ACT from Santa Cruz Biotechnology
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Deltex-4 CRISPR Activation Plasmid (h2) - sc-411695-ACT-2 from Santa Cruz Biotechnology
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Deltex-4 Lentiviral Activation Particles (h) - sc-411695-LAC from Santa Cruz Biotechnology
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Deltex-4 Lentiviral Activation Particles (h2) - sc-411695-LAC-2 from Santa Cruz Biotechnology
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Deltex-4 siRNA (h) - sc-105285 from Santa Cruz Biotechnology
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Deltex-4 shRNA Plasmid (h) - sc-105285-SH from Santa Cruz Biotechnology
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Deltex-4 shRNA (h) Lentiviral Particles - sc-105285-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU132291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7531 from Sigma-Aldrich
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DTX4 siRNA (Human) - CRH8098 from Cohesion Biosciences
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DTX4 - MBS8217284 from MyBioSource
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shRNA set against Human Dtx4 (NM_015177.1) - SHH281513 from Creative biogene
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shRNA set against Human DTX4(NM_015177.1) - SHH017813 from Creative biogene
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Human DTX4 siRNA - orb268600 from Biorbyt
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DTX4 shRNA Plasmid (Human) - CHH8098 from Cohesion Biosciences
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DTX4 miRNA 3'UTR clone - MiUTR1H-03019 from Creative biogene
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