Gene Symbol | DTX4 |
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Entrez Gene | 23220 |
Alt Symbol | RNF155 |
Species | Human |
Gene Type | protein-coding |
Description | deltex 4, E3 ubiquitin ligase |
Other Description | E3 ubiquitin-protein ligase DTX4|RING finger protein 155|deltex 4 homolog|deltex homolog 4|deltex4|protein deltex-4 |
Swissprots | Q0VF38 Q9Y2E6 |
Accessions | EAW73838 Q9Y2E6 AB023154 BAA76781 AF086290 BC015592 BC119011 AAI19012 BC122861 AAI22862 BF195769 XM_006718483 XP_006718546 NM_001300727 NP_001287656 NM_015177 NP_055992 |
Function | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. {ECO:0000250, ECO:0000269|PubMed:22388039}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Top Pathways | Notch signaling pathway |
Deltex-4 (S-17) - sc-246419 from Santa Cruz Biotechnology
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Anti-DTX4 antibody - C-terminal - ab140289 from Abcam
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Anti-DTX4 antibody - N-terminal - ab175837 from Abcam
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Anti-DTX4 Antibody (N-Terminus, AP) - LS-C276910 from LifeSpan Bioscience
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Anti-DTX4 Antibody (N-Terminus, APC) - LS-C276913 from LifeSpan Bioscience
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Anti-DTX4 Antibody (N-Terminus, Biotin) - LS-C276914 from LifeSpan Bioscience
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Anti-DTX4 Antibody (N-Terminus, PE) - LS-C276917 from LifeSpan Bioscience
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Anti-DTX4 Antibody (N-Terminus, FITC) - LS-C276915 from LifeSpan Bioscience
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Anti-DTX4 Antibody (N-Terminus, Azide-free, HRP) - LS-C276916 from LifeSpan Bioscience
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Anti-DTX4 Antibody (N-Terminus) - LS-C327222 from LifeSpan Bioscience
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Anti-DTX4 Antibody (Internal) IHC-plus⢠- LS-B12143 from LifeSpan Bioscience
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Anti-DTX4 Antibody (C-Terminus) - LS-C345190 from LifeSpan Bioscience
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Anti-DTX4 Antibody (aa56-83) - LS-C167560 from LifeSpan Bioscience
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DTX4 Antibody - NBP2-34161 from Novus Biologicals
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DTX4 Antibody - NBP2-32448 from Novus Biologicals
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Anti-DTX4 antibody produced in rabbit - HPA059294 from Sigma-Aldrich
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ANTI-DTX4 (N-TERM) antibody produced in rabbit - SAB1301190 from Sigma-Aldrich
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DTX4 Antibody - C-terminal region (ARP68283_P050) - ARP68283_P050 from Aviva Systems Biology
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DTX4 Antibody - C-terminal region (ARP68284_P050) - ARP68284_P050 from Aviva Systems Biology
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DTX4-Antibody-N-term - AP8872a from Abgent, a WuXi AppTec company
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DTX4 Antibody - N-terminal region (OAAB05466) - OAAB05466 from Aviva Systems Biology
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DTX4 antibody, N-term - GTX80971 from GeneTex
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DTX4 antibody - 25222-1-AP from Acris Antibodies
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DTX4 Antibody - 8057 from ProSci
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DTX4 antibody - 25222-1-AP from Proteintech Group
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