| Gene Symbol |
DTX4
|
| Entrez Gene |
23220
|
| Alt Symbol |
RNF155
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
deltex 4, E3 ubiquitin ligase
|
| Other Description |
E3 ubiquitin-protein ligase DTX4|RING finger protein 155|deltex 4 homolog|deltex homolog 4|deltex4|protein deltex-4
|
| Swissprots |
Q0VF38 Q9Y2E6
|
| Accessions |
EAW73838 Q9Y2E6 AB023154 BAA76781 AF086290 BC015592 BC119011 AAI19012 BC122861 AAI22862 BF195769 XM_006718483 XP_006718546 NM_001300727 NP_001287656 NM_015177 NP_055992
|
| Function |
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. {ECO:0000250, ECO:0000269|PubMed:22388039}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Top Pathways |
Notch signaling pathway
|
