HECW1

Gene Symbol HECW1
Entrez Gene 23072
Alt Symbol NEDL1
Species Human
Gene Type protein-coding
Description HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Other Description E3 ubiquitin-protein ligase HECW1|HECT type E3 ubiquitin ligase|NEDD4-like ubiquitin-protein ligase 1
Swissprots A8MYS3 Q76N89 B4DH42 Q9HCC7 A7E2X0 O15036
Accessions EAL24007 EAW94158 EAW94159 EAW94160 Q76N89 AB002320 BAA20780 AB048365 BAB13352 AK022679 AK090799 BAG52230 AK294918 BAG58003 AL079731 AL536075 BC151227 AAI51228 XM_005249665 XP_005249722 XM_006715670 XP_006715733 XM_006715671 XP_006715734 XM_006715673 XP_006715736 XM_011515219 XP_011513521 XM_011515220 XP_011513522 XM_011515221 XP_011513523 XM_011515222 XP_011513524 XM_011515223 XP_011513525 XM_011515224 XP_011513526 XM_011515225 XP_011513527 XM_011515226 XP_011513528 NM_001287059 NP_001273988 NM_015052 NP_055867
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:14684739}.
Tissue Specificity Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney. {ECO:0000269|PubMed:14684739}.

NEDL1 (S-13) - sc-163125 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-HECW1 antibody - ab121264 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab121264, at 1/15 dilution, staining HECW1 in paraffin-embedded Human cerebral cortex tissue by Immunohistochemistry, showing strong nuclear and cytoplasmic positivity in neuronal cells.

Anti-HECW1 antibody - ab121265 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab121265 at 1/25 dilution staining HECW1 in Paraffin-embedded Human pancreas tissue by Immunohistochemistry.

HECW1 Antibody - NBP1-93645 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: HECW1 Antibody [NBP1-93645] - Staining of human pancreas shows strong nuclear and cytoplasmic positivity in exocrine glandular cells and islet cells.

HECW1 Antibody - NBP1-93644 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: HECW1 Antibody [NBP1-93644] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli and cytoplasm.

Rabbit Anti-HECW1/NEDL1 Polyclonal Antibody - bs-11692R from Bioss

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Anti-HECW1/NEDL1 Polyclonal Antibody, Unconjugated (bs-11692R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-HECW1 antibody produced in rabbit - HPA007609 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HECW1: <B>Cat. No. HPA007609</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human pancreas shows strong nuclear and cytoplasmic positivity in exocrine glandular cells and islet cells.

Anti-HECW1 antibody produced in rabbit - HPA007593 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HECW1: <B>Cat. No. HPA007593</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human cerebral cortex shows strong nuclear and cytoplasmic positivity in neuronal cells.

Rabbit anti-Human HECW1 polyclonal antibody - DPABH-16217 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-HECW1 (aa 356-481) polyclonal antibody - DPABH-16227 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

HECW1 Antibody - 45953 from Signalway Antibody

Prices $189.00, $279.00
Sizes 50 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis HECW1 using K562 whole cell lysates

HECW1 Antibody - DF9479 from Affinity Biosciences

Prices $220.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

HECW1 Antibody - NBP2-58900 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: HECW1 Antibody [NBP2-58900] - Staining of human cell line A549 shows localization to cytosol.

HECW1 antibody - orb399047 from Biorbyt

Host Rabbit
Clonality Polyclonal
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