| Gene Symbol |
HECW1
|
| Entrez Gene |
23072
|
| Alt Symbol |
NEDL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
|
| Other Description |
E3 ubiquitin-protein ligase HECW1|HECT type E3 ubiquitin ligase|NEDD4-like ubiquitin-protein ligase 1
|
| Swissprots |
A8MYS3 Q76N89 B4DH42 Q9HCC7 A7E2X0 O15036
|
| Accessions |
EAL24007 EAW94158 EAW94159 EAW94160 Q76N89 AB002320 BAA20780 AB048365 BAB13352 AK022679 AK090799 BAG52230 AK294918 BAG58003 AL079731 AL536075 BC151227 AAI51228 XM_005249665 XP_005249722 XM_006715670 XP_006715733 XM_006715671 XP_006715734 XM_006715673 XP_006715736 XM_011515219 XP_011513521 XM_011515220 XP_011513522 XM_011515221 XP_011513523 XM_011515222 XP_011513524 XM_011515223 XP_011513525 XM_011515224 XP_011513526 XM_011515225 XP_011513527 XM_011515226 XP_011513528 NM_001287059 NP_001273988 NM_015052 NP_055867
|
| Function |
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:14684739}.
|
| Tissue Specificity |
Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney. {ECO:0000269|PubMed:14684739}.
|
