HECW1

Gene Symbol HECW1
Entrez Gene 23072
Alt Symbol NEDL1
Species Human
Gene Type protein-coding
Description HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Other Description E3 ubiquitin-protein ligase HECW1|HECT type E3 ubiquitin ligase|NEDD4-like ubiquitin-protein ligase 1
Swissprots A8MYS3 Q76N89 B4DH42 Q9HCC7 A7E2X0 O15036
Accessions EAL24007 EAW94158 EAW94159 EAW94160 Q76N89 AB002320 BAA20780 AB048365 BAB13352 AK022679 AK090799 BAG52230 AK294918 BAG58003 AL079731 AL536075 BC151227 AAI51228 XM_005249665 XP_005249722 XM_006715670 XP_006715733 XM_006715671 XP_006715734 XM_006715673 XP_006715736 XM_011515219 XP_011513521 XM_011515220 XP_011513522 XM_011515221 XP_011513523 XM_011515222 XP_011513524 XM_011515223 XP_011513525 XM_011515224 XP_011513526 XM_011515225 XP_011513527 XM_011515226 XP_011513528 NM_001287059 NP_001273988 NM_015052 NP_055867
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:14684739}.
Tissue Specificity Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney. {ECO:0000269|PubMed:14684739}.

NEDL1 CRISPR/Cas9 KO Plasmid (h) - sc-406027 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDL1 HDR Plasmid (h) - sc-406027-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDL1 Double Nickase Plasmid (h) - sc-406027-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDL1 Double Nickase Plasmid (h2) - sc-406027-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDL1 CRISPR Activation Plasmid (h) - sc-406027-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDL1 CRISPR Activation Plasmid (h2) - sc-406027-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDL1 Lentiviral Activation Particles (h) - sc-406027-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDL1 Lentiviral Activation Particles (h2) - sc-406027-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDL1 siRNA (h) - sc-89511 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NEDL1 shRNA Plasmid (h) - sc-89511-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NEDL1 shRNA (h) Lentiviral Particles - sc-89511-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU033001 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9962 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9962 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12630 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12630

HECW1 siRNA (Human) - CRH7977 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HECW1 - MBS8238202 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NEDL1 CRISPR/Cas9 KO Plasmid (h2) - sc-406027-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDL1 HDR Plasmid (h2) - sc-406027-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human HECW1 (NM_015052.3) - SHH311397 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human HECW1(NM_015052.3) - SHH117857 from Creative biogene

Category siRNA
Species Reactivities Human

HECW1 shRNA Plasmid (Human) - CHH7977 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HECW1 miRNA 3'UTR clone - MiUTR1H-04451 from Creative biogene

Species Reactivities Human
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