| Gene Symbol | FABP6 |
|---|---|
| Entrez Gene | 2172 |
| Alt Symbol | I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP |
| Species | Human |
| Gene Type | protein-coding |
| Description | fatty acid binding protein 6, ileal |
| Other Description | GT|gastrotropin|ileal bile acid binding protein|ileal lipid-binding protein|illeal lipid-binding protein|intestinal 15 kDa protein |
| Swissprots | P51161 Q8TBI3 Q07DR7 Q9UGI7 |
| Accessions | CAB65728 CAC81780 EAW61563 EAW61564 EAW61565 EAW61566 P51161 AI208231 BC022489 AAH22489 DQ132786 ABA12611 HQ448339 ADQ32819 U19869 AAB82751 X90908 CAA62415 XM_006714830 XP_006714893 XM_011534463 XP_011532765 NM_001040442 NP_001035532 NM_001130958 NP_001124430 NM_001445 NP_001436 |
| Function | Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis. {ECO:0000269|PubMed:17909007}. |
| Subcellular Location | Isoform 1: Cytoplasm. |
| Tissue Specificity | Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. {ECO:0000269|PubMed:17909007}. |
| Top Pathways | PPAR signaling pathway |