| Gene Symbol |
FABP6
|
| Entrez Gene |
2172
|
| Alt Symbol |
I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fatty acid binding protein 6, ileal
|
| Other Description |
GT|gastrotropin|ileal bile acid binding protein|ileal lipid-binding protein|illeal lipid-binding protein|intestinal 15 kDa protein
|
| Swissprots |
P51161 Q8TBI3 Q07DR7 Q9UGI7
|
| Accessions |
CAB65728 CAC81780 EAW61563 EAW61564 EAW61565 EAW61566 P51161 AI208231 BC022489 AAH22489 DQ132786 ABA12611 HQ448339 ADQ32819 U19869 AAB82751 X90908 CAA62415 XM_006714830 XP_006714893 XM_011534463 XP_011532765 NM_001040442 NP_001035532 NM_001130958 NP_001124430 NM_001445 NP_001436
|
| Function |
Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis. {ECO:0000269|PubMed:17909007}.
|
| Subcellular Location |
Isoform 1: Cytoplasm.
|
| Tissue Specificity |
Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. {ECO:0000269|PubMed:17909007}.
|
| Top Pathways |
PPAR signaling pathway
|
![Western Blot: FABP6 Overexpression Lysate (Adult Normal) [NBL1-10422] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FABP6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7891_FABP6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10422-img0002.jpg)